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Population expansion and gene flow in Giardia duodenalis as revealed by triosephosphate isomerase gene

Overview of attention for article published in Parasites & Vectors, September 2015
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

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3 X users
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1 Facebook page

Citations

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28 Mendeley
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Title
Population expansion and gene flow in Giardia duodenalis as revealed by triosephosphate isomerase gene
Published in
Parasites & Vectors, September 2015
DOI 10.1186/s13071-015-1084-y
Pubmed ID
Authors

Seow Huey Choy, Mohammed A. K. Mahdy, Hesham M. Al-Mekhlafi, Van Lun Low, Johari Surin

Abstract

Giardia duodenalis is a protozoan parasite that can cause significant diarrhoeal diseases. Knowledge of population genetics is a prerequisite for ascertaining the invasion patterns of this parasite. In order to infer evolutionary patterns that could not be uncovered based on the morphological features, a population genetic study with the incorporation of molecular marker was carried out to access the genetic structure of G. duodenalis isolated from the Malaysian population and the global populations. A total of 154 samples positive for Giardia, collected from different Malaysian communities, were subjected to DNA amplification and sequencing targeting three genetic loci (tpi, gdh, and bg). The tpi sequences together with sequences from the global data obtained from the NCBI GenBank were used for genetic diversity analyses including identification of haplotypes, haplotype diversity, nucleotide diversity, Tajima's D and Fu and Li's D, gene flow and genetic differentiation tests. Analysis of the Malaysian and global data showed that assemblages A, B, and E (the most prevalent assemblages in humans and animals), have different levels of genetic diversity. Assemblage B had the highest level of both haplotype diversity and nucleotide diversity, followed by assemblage E. The analysis also revealed population expansion and high gene flow in all assemblages. No clear genetic structure was observed across five continents (i.e., the Americas, Europe, Asia, Australia and Africa). However, median joining network of assemblage B formed a cluster that was exclusively isolated from Asia while other haplotypes were well dispersed across the continents. This study provides new insight into the genetic diversity of Giardia assemblages in different geographical regions. The significant result shown by gene flow and genetic differentiation analyses as well as test of neutrality among the populations should have brought a clearer picture to the dynamics and distribution of Giardia infection.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 21%
Student > Master 6 21%
Student > Ph. D. Student 4 14%
Other 3 11%
Lecturer 1 4%
Other 3 11%
Unknown 5 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 25%
Veterinary Science and Veterinary Medicine 3 11%
Biochemistry, Genetics and Molecular Biology 3 11%
Medicine and Dentistry 3 11%
Immunology and Microbiology 2 7%
Other 4 14%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2015.
All research outputs
#13,447,737
of 22,828,180 outputs
Outputs from Parasites & Vectors
#2,455
of 5,463 outputs
Outputs of similar age
#126,987
of 268,885 outputs
Outputs of similar age from Parasites & Vectors
#52
of 144 outputs
Altmetric has tracked 22,828,180 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,463 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,885 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 144 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.