Title |
Falciparum malaria molecular drug resistance in the Democratic Republic of Congo: a systematic review
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Published in |
Malaria Journal, September 2015
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DOI | 10.1186/s12936-015-0892-z |
Pubmed ID | |
Authors |
Dieudonné Makaba Mvumbi, Jean-Marie Kayembe, Hippolyte Situakibanza, Thierry L. Bobanga, Célestin N. Nsibu, Georges L. Mvumbi, Pierrette Melin, Patrick De Mol, Marie-Pierre Hayette |
Abstract |
Malaria cases were estimated to 207 million in 2013. One of the problems of malaria control is the emergence and spread of Plasmodium falciparum strains that become resistant to almost all drugs available. Monitoring drug resistance is essential for early detection and subsequent prevention of the spread of drug resistance by timely changes of treatment policy. This review was performed to gather all data available on P. falciparum molecular resistance in DR Congo, as baseline for future assessments. The search for this review was undertaken using the electronic databases PubMed and Google Scholar using the terms "malaria", "Congo", "resistance", "molecular", "antimalarial", "efficacy". Articles were classified based on year of collecting, year of publication, sample size and characteristics, molecular markers analysed and polymorphisms detected. Thirteen articles were included and five genes have been analysed in these studies: pfcrt, pfdhps, pfdhfr, pfmdr1 and K13-propeller. The majority of studies included were not representative of the whole country. This systematic review demonstrates the lack of molecular resistance studies in DRC. Only 13 studies were identified in almost 15 years. The MOH must implement a national surveillance system for monitoring malaria drug resistance and this surveillance should be conducted frequently and country-representative. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 13% |
United Kingdom | 1 | 13% |
Kenya | 1 | 13% |
Unknown | 5 | 63% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Kenya | 1 | 1% |
Unknown | 86 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 22 | 25% |
Researcher | 11 | 13% |
Student > Postgraduate | 8 | 9% |
Student > Ph. D. Student | 8 | 9% |
Student > Bachelor | 4 | 5% |
Other | 16 | 18% |
Unknown | 19 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 30% |
Agricultural and Biological Sciences | 13 | 15% |
Biochemistry, Genetics and Molecular Biology | 6 | 7% |
Immunology and Microbiology | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 12 | 14% |
Unknown | 24 | 27% |