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The Danish 22q11 research initiative

Overview of attention for article published in BMC Psychiatry, September 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

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6 X users
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1 Facebook page
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1 Google+ user

Citations

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11 Dimensions

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165 Mendeley
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Title
The Danish 22q11 research initiative
Published in
BMC Psychiatry, September 2015
DOI 10.1186/s12888-015-0594-7
Pubmed ID
Authors

Henriette Schmock, Anders Vangkilde, Kit Melissa Larsen, Elvira Fischer, Michelle Rosgaard Birknow, Jens Richardt Møllegaard Jepsen, Charlotte Olesen, Flemming Skovby, Kerstin Jessica Plessen, Morten Mørup, Ollie Hulme, William Frans Christiaan Baaré, Michael Didriksen, Hartwig Roman Siebner, Thomas Werge, Line Olsen

Abstract

Neurodevelopmental brain disorders such as schizophrenia, autism and attention deficit hyperactivity disorder are complex disorders with heterogeneous etiologies. Schizophrenia and autism are difficult to treat and often cause major individual suffering largely owing to our limited understanding of the disease biology. Thus our understanding of the biological pathogenesis needs to be substantiated to enable development of more targeted treatment options with improved efficacy. Insights into the pre-morbid disease dynamics, the morbid condition and the underlying biological disease mechanisms may come from studies of subjects with homogenous etiologies. Breakthroughs in psychiatric genetics have shown that several genetic anomalies predispose for neurodevelopmental brain disorders. We have established a Danish research initiative to study the common microdeletion at chromosome 22q11.2, which is one of the genetic anomalies that confer high risk of schizophrenia, autism and attention deficit hyperactivity disorder. The study applies a "cause-to-outcome" strategy to identify pre-morbid pathogenesis and underlying biological disease mechanisms of psychosis and secondarily the morbid condition of autism and attention deficit hyperactivity disorder. We use a population based epidemiological design to inform on disease prevalence, environmental risk factors and familial disposition for mental health disorders and a case control study design to map the functional effects across behavioral and neurophysiological traits of the 22q11 deletion in a recruited sample of Danish individuals. Identification of predictive pre-morbid clinical, cognitive, functional and structural brain alterations in 22q11 deletion carriers may alter current clinical practice from symptomatic therapy of manifest mental illness into early intervention strategies, which may also be applicable to at risk subjects without known etiology. Hopefully new insights into the biological disease mechanisms, which are mandatory for novel drug developments, can improve the outcome of the pharmacological interventions in psychiatry.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 <1%
Unknown 164 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 27 16%
Student > Ph. D. Student 23 14%
Researcher 22 13%
Student > Bachelor 18 11%
Student > Doctoral Student 11 7%
Other 28 17%
Unknown 36 22%
Readers by discipline Count As %
Psychology 33 20%
Medicine and Dentistry 31 19%
Neuroscience 12 7%
Nursing and Health Professions 11 7%
Social Sciences 8 5%
Other 22 13%
Unknown 48 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2017.
All research outputs
#6,241,502
of 22,828,180 outputs
Outputs from BMC Psychiatry
#2,158
of 4,692 outputs
Outputs of similar age
#75,075
of 272,396 outputs
Outputs of similar age from BMC Psychiatry
#24
of 75 outputs
Altmetric has tracked 22,828,180 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 4,692 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.9. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,396 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.