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NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats

Overview of attention for article published in Journal of Neuroinflammation, September 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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1 blog
twitter
1 tweeter

Citations

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41 Mendeley
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Title
NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats
Published in
Journal of Neuroinflammation, September 2015
DOI 10.1186/s12974-015-0395-4
Pubmed ID
Authors

Antwoine Flowers, Jea-Young Lee, Sandra Acosta, Charles Hudson, Brent Small, Cyndy D. Sanberg, Paula C. Bickford, Bethany Grimmig

Abstract

Aging is associated with a decline in stem cell proliferation that is thought to be a result of dysregulated signaling in the neurogenic niche. This results in a diminished and less efficient pool of progenitors. The Wnt pathway plays a key role in the proliferation and differentiation of progenitor cells. Recent publications suggest that the age-related decline in the function of Wnt is a contributor to age-dependent decline in neural progenitors. Similarly, the aged neurogenic niche is characterized by higher levels of inflammatory cytokines. This increased inflammation contributes to the declining function of neural progenitor cells. NT-020, a proprietary blend of polyphenols, has been shown to increase proliferation of neural progenitors and improve cognitive function in aged rats. In this study, we examined the neurogenic niche in the subgranular zone of the dentate gyrus (SGZ) and the subventricular zone (SVZ) of young and aged rats to determine if dietary supplementation with NT-020 could regulate inflammation and oxidative stress response pathways in neurons, astrocytes, and microglia. Further, we examined NT-020's ability to modulate Wnt signaling in the aged neurogenic niche. To accomplish this, we utilized gene PCR arrays and immunohistochemistry. We observed an increase in nuclear localization of immunopositive labeling of β-catenin, HO-1, and Nrf2 in all subsets of cell types in both young and aged rats in the SGZ and SVZ following NT-020 treatment. NeuN-positive cells showed a basal increase in nuclear β-catenin in the aged rats, which was not observed in doublecortin (DCX)-labeled cells, microglia, or astrocytes. Reverse transcription polymerase chain reaction (RT-PCR) analysis of isolated hippocampal tissue revealed that a significant percent of genes involved with inflammation are affected by treatment with NT-020. In addition, several genes that regulate Wnt activity were affected by supplementation. The results suggest that NT-020 activates oxidative stress response pathways and supports pro-neurogenic gene expression in the hippocampus. This may represent the mechanism by which the NT-020 formula enhances performance in learning and memory tasks in aged mice.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 17%
Student > Bachelor 6 15%
Student > Master 5 12%
Other 4 10%
Student > Ph. D. Student 4 10%
Other 7 17%
Unknown 8 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 24%
Neuroscience 7 17%
Medicine and Dentistry 5 12%
Psychology 2 5%
Biochemistry, Genetics and Molecular Biology 2 5%
Other 3 7%
Unknown 12 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2017.
All research outputs
#1,656,753
of 11,626,228 outputs
Outputs from Journal of Neuroinflammation
#222
of 1,321 outputs
Outputs of similar age
#44,018
of 242,371 outputs
Outputs of similar age from Journal of Neuroinflammation
#11
of 52 outputs
Altmetric has tracked 11,626,228 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,321 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,371 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.