Title |
Do women with statin-related myalgias have low vitamin D levels?
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Published in |
BMC Research Notes, September 2015
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DOI | 10.1186/s13104-015-1356-9 |
Pubmed ID | |
Authors |
Margo Minissian, Megha Agarwal, Chrisandra Shufelt, Puja K. Mehta, Talya Waldman, Greg Lentz, Galen Cook-Wiens, Jo-Ann Eastwood, C. Noel Bairey Merz |
Abstract |
Statin intolerance is often due to myalgias. Severe vitamin D deficiency is characterized by musculoskeletal pain. We hypothesized that statin-intolerance is associated with vitamin D deficiency. To determine whether there is an association between statin-intolerance and vitamin D deficiency in a retrospective observational analysis. We evaluated 20 female patients with prior myalgia-related daily dose statin intolerance on an alternative day statin dosing protocol of twice weekly for 4 weeks followed by advancement to daily dosing, as tolerated. Fasting baseline and follow-up lipid and 25-hydroxy-vitamin D (25-OHD) levels were obtained by chart review. The group median age was 61 ± 13 years old and BMI was 27 ± 7 kg/m(2). Women who remained on alternative day statin dosing (n = 16) compared to women on daily dosing (n = 4) had a significantly lower group mean 25-OHD (mean 29 ± 11.23 vs. 47.5 ± 23.53 ng/ml p = 0.0307 respectively). In women with prior myalgia-related statin intolerance, vitamin D levels were significantly lower in women who remained on alternative day dosing compared to those who were tolerant of daily dosing. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 75% |
Canada | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Scientists | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
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Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 31% |
Student > Master | 2 | 13% |
Professor | 2 | 13% |
Other | 1 | 6% |
Lecturer | 1 | 6% |
Other | 2 | 13% |
Unknown | 3 | 19% |
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Medicine and Dentistry | 9 | 56% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
Neuroscience | 1 | 6% |
Mathematics | 1 | 6% |
Unknown | 3 | 19% |