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The Acute Chest Syndrome in Cameroonian children living with sickle cell disease

Overview of attention for article published in BMC Pediatrics, September 2015
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Title
The Acute Chest Syndrome in Cameroonian children living with sickle cell disease
Published in
BMC Pediatrics, September 2015
DOI 10.1186/s12887-015-0454-0
Pubmed ID
Authors

Jobert Richie N. Nansseu, Anastasie Nicole Alima Yanda, David Chelo, Sandra A. Tatah, Hubert D. Mbassi Awa, Judith Seungue, Paul Olivier N. Koki

Abstract

Although sub-Saharan Africa (SSA) is particularly affected by sickle cell disease (SCD), there is dearth of research on this topic in the region, specifically targeting the magnitude of SCD-related complications. We therefore conducted this study to determine the burden of acute chest syndrome (ACS) and describe its clinical and therapeutic aspects among SCD children in Cameroon, a SSA country. This was a retrospective study carried-out from September 2013 to June 2014 at the SCD unit of the Mother and Child Centre of the Chantal Biya Foundation, a pediatric reference centre in Yaoundé, Cameroon. We enrolled all SCD children with confirmed diagnosis of ACS, and recorded their clinical presentation at admission along with their evolution during hospitalization. Twenty one cases of ACS were identified during the study period, from 338 hospitalizations of children with SCD. Ages ranged from 11 months to 16 years with a mean (standard deviation) of 5.5 (3.4) years, and a male/female sex ratio of 3.2/1. We noticed relatively low levels of HbF, from 6.4 to 21.9 % with a mean of 14.6 % (6.0 %). The three main symptoms at admission were fever (90.5 %), cough (81 %) and chest pains (28.6 %). Two patients (9.5 %) developed ACS 2 days after admission. The mean values of leukocytes, neutrophils, serum CRP, serum LDH and hemoglobin were respectively 32479.4 (17862.3)/mm(3), 23476 (11543.7)/mm(3), 228.2 (132.6) mg/l, 3452.3 (2916.3) IU/l and 6.5 (1.2) g/dl. The main localizations of radiological alveolar consolidations were the lower lobes (90.5 %). Treatment associated broad-spectrum antibiotics (100 %), hydration (100 %), analgesics (43.2 %), whole blood transfusion (66.7 %), and oxygen supplementation (33.3 %). Blood transfusion significantly improved hemoglobin level (p = 0.039). The duration of hospitalization, the mean of which was 6.8 (3.1) days, was influenced by none of the tested variables (all p values > 0.05). ACS is frequent among SCD children in our milieu. Its etiologies seem to be multifactorial. Patients' parents should be educated to recognize early signs and symptoms of the disease, and consult rapidly. Additionally, clinicians must be trained to diagnose ACS, and manage it promptly and efficiently to avoid its related catastrophic consequences.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Cameroon 1 1%
Unknown 81 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 17%
Researcher 8 10%
Student > Bachelor 7 9%
Student > Doctoral Student 7 9%
Student > Postgraduate 7 9%
Other 14 17%
Unknown 25 30%
Readers by discipline Count As %
Medicine and Dentistry 29 35%
Nursing and Health Professions 6 7%
Social Sciences 5 6%
Biochemistry, Genetics and Molecular Biology 5 6%
Agricultural and Biological Sciences 3 4%
Other 7 9%
Unknown 27 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2023.
All research outputs
#16,492,041
of 25,058,309 outputs
Outputs from BMC Pediatrics
#2,090
of 3,368 outputs
Outputs of similar age
#158,139
of 280,293 outputs
Outputs of similar age from BMC Pediatrics
#35
of 60 outputs
Altmetric has tracked 25,058,309 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,368 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,293 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.