Title |
Anti‐IgE therapy for IgE‐mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE+ B cells
|
---|---|
Published in |
Clinical and Translational Allergy, July 2018
|
DOI | 10.1186/s13601-018-0213-z |
Pubmed ID | |
Authors |
Jiayun Hu, Jiajie Chen, Lanlan Ye, Zelang Cai, Jinlu Sun, Kunmei Ji |
Abstract |
Allergic diseases are inflammatory disorders that involve many types of cells and factors, including allergens, immunoglobulin (Ig)E, mast cells, basophils, cytokines and soluble mediators. Among them, IgE plays a vital role in the development of acute allergic reactions and chronic inflammatory allergic diseases, making its control particularly important in the treatment of IgE-mediated allergic diseases. This review provides an overview of the current state of IgE targeted therapy development, focusing on three areas of translational research: IgE neutralization in blood; IgE-effector cell elimination; and IgE+ B cell reduction. IgE-targeted medicines such as FDA approved drug Xolair (Omalizumab) represent a promising avenue for treating IgE-mediated allergic diseases given the pernicious role of IgE in disease progression. Additionally, targeted therapy for IgE-mediated allergic diseases may be advanced through cellular treatments, including the modification of effector cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 8 | 17% |
Romania | 8 | 17% |
United Kingdom | 2 | 4% |
Netherlands | 2 | 4% |
Jordan | 1 | 2% |
Japan | 1 | 2% |
Germany | 1 | 2% |
Australia | 1 | 2% |
Chile | 1 | 2% |
Other | 8 | 17% |
Unknown | 14 | 30% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 29 | 62% |
Scientists | 11 | 23% |
Practitioners (doctors, other healthcare professionals) | 7 | 15% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 117 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 23 | 20% |
Student > Master | 13 | 11% |
Student > Ph. D. Student | 11 | 9% |
Researcher | 9 | 8% |
Student > Postgraduate | 7 | 6% |
Other | 19 | 16% |
Unknown | 35 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 20 | 17% |
Medicine and Dentistry | 20 | 17% |
Immunology and Microbiology | 11 | 9% |
Agricultural and Biological Sciences | 8 | 7% |
Chemistry | 7 | 6% |
Other | 15 | 13% |
Unknown | 36 | 31% |