↓ Skip to main content

Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence

Overview of attention for article published in BMC Cancer, November 2011
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
48 Dimensions

Readers on

mendeley
54 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence
Published in
BMC Cancer, November 2011
DOI 10.1186/1471-2407-11-483
Pubmed ID
Authors

Georgina Hernandez-Flores, Pablo C Ortiz-Lazareno, Jose Manuel Lerma-Diaz, Jorge R Dominguez-Rodriguez, Luis F Jave-Suarez, Adriana del C Aguilar-Lemarroy, Ruth de Celis-Carrillo, Susana del Toro-Arreola, Yessica C Castellanos-Esparza, Alejandro Bravo-Cuellar

Abstract

Worldwide, cervical cancer is the second most common causes of cancer in women and represents an important mortality rate. Cisplatin (CIS) is a very important antitumoral agent and can lead tumor cells toward two important cellular states: apoptosis and senescence. In some types of cancers pentoxifylline (PTX) sensitizes these cells to the toxic action of chemotherapeutics drugs such as adriamycin, inducing apoptosis. In the present work, we studied in vitro whether PTX alone or in combination with CIS induces apoptosis and/or senescence in cervix cancer HeLa and SiHa cell lines infected with HPV types 16 and 18, respectively, as well as in immortalized keratinocytyes HaCaT cells.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
United States 1 2%
Unknown 52 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 28%
Researcher 10 19%
Student > Bachelor 7 13%
Student > Master 4 7%
Student > Doctoral Student 3 6%
Other 4 7%
Unknown 11 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 22%
Biochemistry, Genetics and Molecular Biology 11 20%
Medicine and Dentistry 10 19%
Nursing and Health Professions 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 4 7%
Unknown 13 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2011.
All research outputs
#20,150,151
of 22,656,971 outputs
Outputs from BMC Cancer
#6,478
of 8,238 outputs
Outputs of similar age
#130,969
of 142,871 outputs
Outputs of similar age from BMC Cancer
#77
of 95 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,238 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 142,871 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.