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Associations of genetic variations in EYA4, GRHL2 and DFNA5 with noise-induced hearing loss in Chinese population: a case- control study

Overview of attention for article published in Environmental Health, September 2015
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Title
Associations of genetic variations in EYA4, GRHL2 and DFNA5 with noise-induced hearing loss in Chinese population: a case- control study
Published in
Environmental Health, September 2015
DOI 10.1186/s12940-015-0063-2
Pubmed ID
Authors

Xuhui Zhang, Yi Liu, Lei Zhang, Zhangping Yang, Luoxian Yang, Xuchu Wang, CaiXia Jiang, Qiang Wang, Yuyong Xia, Yanjuan Chen, Ou Wu, Yimin Zhu

Abstract

Both environmental and genetic factors are attributable to the incidence of noise-induced hearing loss (NIHL). The purpose of this study was to examine the associations between genetic variations in the EYA4, GRHL2 and DFNA5 genes and the risk to noise-induced hearing loss (NIHL) in a Chinese population. A case-control study was conducted with 476 NIHL workers and 475 normal hearing workers matched with gender, years of noise exposure, and intensity of noise exposure. Twelve tag single-nucleotide polymorphisms (SNP) in the EYA4, GRHL2 and DFNA5 genes were genotyped using nanofluidic dynamic arrays on the Fluidigm platform. Multiple logistic regression was used to analyze the associations of genetic variations with NIHL adjusted by age, smoking/drinking status, and cumulative noise exposure and their interactions with noise exposure. The SNPs of rs3777781and rs212769 in the EYA4 gene were significantly associated with NIHL risk. In rs3777781, comparing with the subjects carrying with TT types, the carriers with AT and AA genotypes had the decreased risk of NIHL (OR = 0.721, 95 % CI = 0.522 - 0.996). In rs212769, the AG and AA carriers had increased NIHL risk (OR = 1.430, 95 % CI = 1.014 - 2.016) compared with the subjects with GG genotype. Rs666026 in the associated GRHL2 gene and rs2521758 in the DFNA5 gene were marginally t associated with NIHL (P = 0.065 and 0.052, respectively). Rs2521758 and rs212769 had significantly interacted with noise exposure (P < 0.05). Genetic variations in the EYA4, GRHL2 and DFNA5 genes and their interactions with occupational noise exposure may play an important role in the incidence of NIHL.

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Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 21%
Other 5 15%
Student > Doctoral Student 3 9%
Student > Bachelor 3 9%
Professor 3 9%
Other 6 18%
Unknown 7 21%
Readers by discipline Count As %
Medicine and Dentistry 5 15%
Agricultural and Biological Sciences 4 12%
Nursing and Health Professions 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Engineering 2 6%
Other 7 21%
Unknown 11 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2015.
All research outputs
#20,292,660
of 22,829,083 outputs
Outputs from Environmental Health
#1,343
of 1,490 outputs
Outputs of similar age
#230,515
of 274,665 outputs
Outputs of similar age from Environmental Health
#24
of 24 outputs
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