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Antidepressant-like effects of methanolic extract of Bacopa monniera in mice

Overview of attention for article published in BMC Complementary and Alternative Medicine, September 2015
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Title
Antidepressant-like effects of methanolic extract of Bacopa monniera in mice
Published in
BMC Complementary and Alternative Medicine, September 2015
DOI 10.1186/s12906-015-0866-2
Pubmed ID
Authors

Abdul Mannan, Ariful Basher Abir, Rashidur Rahman

Abstract

Bacopa monniera has been used as a cure for various ailments that include anxiety, epileptic disorders, dementia, blood purifier, cough and rheumatism, and some important local uses of the plant are in dermatitis, anemia, diabetes, promote fertility and prevent miscarriage for many years in Bangladesh. According to this background, the aim of the study was to evaluate the antidepressant-like effect of the methanolic extract of B. monniera (MEBM) in different behavioral models such as forced swimming test (FST), measurement of locomotor activity test (MLAT) and tail suspension test (TST) on mice after two weeks treatment. Mice were divided into five groups (n = 5/group): control group (deionized water), standard group where Imipramine hydrochloride (30 mg/kg) was used as standard drug and three test groups where three doses of the methanolic extract of B. monniera (MEBM) (50, 100, and 200 mg/kg) was used for two weeks treatment. All the drug and test samples were administered via gavage through oral route. To assess the antidepressant-like effect of MEBM forced swimming test (FST), tail suspension test (TST) and measurement of locomotor activity test (MLAT) have been done in mice. The results showed that a strong and dose-dependent antidepressant effects in different mice models. The main findings of the MEBM significantly reduced the duration of immobility times in the forced swimming test (p < 0.001). Likewise, the extract significantly decreased the immobility time in the tail suspension test (p < 0.001). Moreover, we employed an additional measurement of locomotor activity test to check the motor stimulating activity of the MEBM. The extract also significantly increased the locomotion, rearing and defecation effects in comparison to the control group (p < 0.001). The present results clearly demonstrate that the methanolic extract of B. monniera possesses antidepressant-like activity in the animal behavioral models. The current study warrants further investigation into identification of the active compounds in herbal medicines, in particular extract of B. monniera with antidepressant-like effects.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
India 1 1%
Unknown 88 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 23 26%
Student > Ph. D. Student 11 12%
Student > Master 8 9%
Researcher 6 7%
Lecturer 4 4%
Other 10 11%
Unknown 28 31%
Readers by discipline Count As %
Medicine and Dentistry 15 17%
Pharmacology, Toxicology and Pharmaceutical Science 15 17%
Agricultural and Biological Sciences 8 9%
Nursing and Health Professions 5 6%
Biochemistry, Genetics and Molecular Biology 4 4%
Other 10 11%
Unknown 33 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2015.
All research outputs
#12,182,009
of 15,325,959 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,984
of 2,963 outputs
Outputs of similar age
#172,375
of 250,171 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#1
of 1 outputs
Altmetric has tracked 15,325,959 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,963 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,171 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them