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Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma

Overview of attention for article published in Molecular Cancer, September 2015
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Title
Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma
Published in
Molecular Cancer, September 2015
DOI 10.1186/s12943-015-0444-8
Pubmed ID
Authors

Kwan Yeung Wong, Zhenhai Li, Xiaoqin Zhang, Gilberto Ka Kit Leung, Godfrey Chi-fung Chan, Chor Sang Chim

Abstract

In multiple myeloma, a long non-coding RNA, KIAA0495 (alias PDAM/TP73-AS1), had been found progressively downregulated from normal plasma cell to benign monoclonal gammopathy of undetermined significance to symptomatic myeloma. Herein, by methylation-specific PCR, the putative KIAA0495 promoter was found unmethylated in all healthy controls (N = 14) but methylated in 50 % of myeloma cell lines (N = 10). KIAA0495 methylation was shown inversely correlated with KIAA0495 expression. However, KIAA0495 methylation was detected in none of both primary myeloma samples at diagnosis (N = 61) and at relapse/progression (N = 16). Collectively, despite frequently methylated in cell lines, KIAA0495 methylation appeared unimportant in the pathogenesis or progression of myeloma.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 28%
Researcher 5 28%
Other 2 11%
Professor 1 6%
Student > Doctoral Student 1 6%
Other 2 11%
Unknown 2 11%
Readers by discipline Count As %
Medicine and Dentistry 7 39%
Biochemistry, Genetics and Molecular Biology 3 17%
Agricultural and Biological Sciences 2 11%
Neuroscience 2 11%
Nursing and Health Professions 1 6%
Other 1 6%
Unknown 2 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2015.
All research outputs
#14,238,817
of 22,829,083 outputs
Outputs from Molecular Cancer
#902
of 1,721 outputs
Outputs of similar age
#142,180
of 274,838 outputs
Outputs of similar age from Molecular Cancer
#15
of 38 outputs
Altmetric has tracked 22,829,083 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,721 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,838 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.