Title |
Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity
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Published in |
BMC Gastroenterology, November 2011
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DOI | 10.1186/1471-230x-11-125 |
Pubmed ID | |
Authors |
Runkuan Yang, Shutian Zhang, Henri Kajander, Shengtao Zhu, Marja-Leena Koskinen, Jyrki Tenhunen |
Abstract |
Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Liver regeneration is a vital process for survival after a toxic insult. Since hepatocytes are mostly in a quiescent state (G0), the regeneration process requires the priming of hepatocytes by cytokines such as TNF-α and IL-6. Ringer's lactate solution (RLS) has been shown to increase serum TNF-α and IL-6 in patients and experimental animals; in addition, RLS also provides lactate, which can be used as an alternative metabolic fuel to meet the higher energy demand by liver regeneration. Therefore, we tested whether RLS therapy improves liver recovery after APAP overdose. |
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Researcher | 5 | 25% |
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