Title |
The Murray collection of pre-antibiotic era Enterobacteriacae: a unique research resource
|
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Published in |
Genome Medicine, September 2015
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DOI | 10.1186/s13073-015-0222-7 |
Pubmed ID | |
Authors |
Kate S. Baker, Edward Burnett, Hannah McGregor, Ana Deheer-Graham, Christine Boinett, Gemma C. Langridge, Alexander M. Wailan, Amy K. Cain, Nicholas R. Thomson, Julie E. Russell, Julian Parkhill |
Abstract |
Studies of historical isolates inform on the evolution and emergence of important pathogens and phenotypes, including antimicrobial resistance. Crucial to studying antimicrobial resistance are isolates that predate the widespread clinical use of antimicrobials. The Murray collection of several hundred bacterial strains of pre-antibiotic era Enterobacteriaceae is an invaluable resource of historical strains from important pathogen groups. Studies performed on the Collection to date merely exemplify its potential, which will only be realised through the continued effort of many scientific groups. To enable that aim, we announce the public availability of the Murray collection through the National Collection of Type Cultures, and present associated metadata with whole genome sequence data for over half of the strains. Using this information we verify the metadata for the collection with regard to subgroup designations, equivalence groupings and plasmid content. We also present genomic analyses of population structure and determinants of mobilisable antimicrobial resistance to aid strain selection in future studies. This represents an invaluable public resource for the study of these important pathogen groups and the emergence and evolution of antimicrobial resistance. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 12 | 31% |
United States | 4 | 10% |
Chile | 2 | 5% |
Australia | 2 | 5% |
Venezuela, Bolivarian Republic of | 1 | 3% |
Mexico | 1 | 3% |
Unknown | 17 | 44% |
Demographic breakdown
Type | Count | As % |
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Scientists | 27 | 69% |
Members of the public | 12 | 31% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 72 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 21 | 29% |
Student > Ph. D. Student | 12 | 17% |
Student > Master | 7 | 10% |
Student > Bachelor | 6 | 8% |
Student > Doctoral Student | 3 | 4% |
Other | 5 | 7% |
Unknown | 18 | 25% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 20 | 28% |
Biochemistry, Genetics and Molecular Biology | 14 | 19% |
Medicine and Dentistry | 5 | 7% |
Immunology and Microbiology | 5 | 7% |
Computer Science | 3 | 4% |
Other | 7 | 10% |
Unknown | 18 | 25% |