Report for: The different axes of the mammalian mitochondrial unfolded protein response

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Title	The different axes of the mammalian mitochondrial unfolded protein response
Published in	BMC Biology, July 2018
DOI	10.1186/s12915-018-0548-x
Pubmed ID	30049264
Authors	Christian Münch
Abstract	Mitochondria are sensitive to numerous environmental stresses, which can lead to activation of mitochondrial stress responses (MSRs). Of particular recent interest has been the mitochondrial unfolded protein response (UPRmt), activated to restore protein homeostasis (proteostasis) upon mitochondrial protein misfolding. Several axes of the UPRmt have been described, creating some confusion as to the nature of the different responses. While distinct molecularly, these different axes are likely mutually beneficial and activated in parallel. This review aims at describing and distinguishing the different mammalian MSR/UPRmt axes to define key processes and members and to examine the involvement of protein misfolding.

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Twitter Demographics

The data shown below were collected from the profiles of 19 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Geographical breakdown

Country	Count	As %
United States	4	21%
Canada	2	11%
Australia	1	5%
Sweden	1	5%
United Kingdom	1	5%
Germany	1	5%
Guinea	1	5%
Unknown	8	42%

Demographic breakdown

Type	Count	As %
Members of the public	9	47%
Scientists	8	42%
Practitioners (doctors, other healthcare professionals)	1	5%
Science communicators (journalists, bloggers, editors)	1	5%

Mendeley readers

The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	138	100%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	24	17%
Student > Bachelor	24	17%
Researcher	19	14%
Student > Master	12	9%
Student > Doctoral Student	10	7%
Other	15	11%
Unknown	34	25%

Readers by discipline	Count	As %
Biochemistry, Genetics and Molecular Biology	52	38%
Agricultural and Biological Sciences	18	13%
Medicine and Dentistry	9	7%
Pharmacology, Toxicology and Pharmaceutical Science	6	4%
Neuroscience	5	4%
Other	13	9%
Unknown	35	25%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2018.

All research outputs

#2,456,708

of 17,986,329 outputs

Outputs from BMC Biology

#695

of 1,557 outputs

Outputs of similar age

#58,187

of 287,213 outputs

Outputs of similar age from BMC Biology

of 1 outputs

Altmetric has tracked 17,986,329 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 1,557 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.0. This one has gotten more attention than average, scoring higher than 55% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,213 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.

We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them

The different axes of the mammalian mitochondrial unfolded protein response

About this Attention Score

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Geographical breakdown

Demographic breakdown

Mendeley readers

Geographical breakdown

Demographic breakdown

Attention Score in Context