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Neuromelanin is an immune stimulator for dendritic cells in vitro

Overview of attention for article published in BMC Neuroscience, November 2011
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Title
Neuromelanin is an immune stimulator for dendritic cells in vitro
Published in
BMC Neuroscience, November 2011
DOI 10.1186/1471-2202-12-116
Pubmed ID
Authors

Uwe Oberländer, Katrien Pletinckx, Anja Döhler, Nora Müller, Manfred B Lutz, Thomas Arzberger, Peter Riederer, Manfred Gerlach, Eleni Koutsilieri, Carsten Scheller

Abstract

Parkinson's disease (PD) is characterized at the cellular level by a destruction of neuromelanin (NM)-containing dopaminergic cells and a profound reduction in striatal dopamine. It has been shown recently that anti-melanin antibodies are increased in sera of Parkinson patients, suggesting that NM may act as an autoantigen. In this study we tested whether NM is being recognized by dendritic cells (DCs), the major cell type for inducing T- and B-cell responses in vivo. This recognition of NM by DCs is a prerequisite to trigger an adaptive autoimmune response directed against NM-associated structures.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Luxembourg 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 21%
Student > Master 9 16%
Researcher 7 12%
Student > Bachelor 5 9%
Student > Doctoral Student 5 9%
Other 9 16%
Unknown 10 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 25%
Medicine and Dentistry 10 18%
Biochemistry, Genetics and Molecular Biology 7 12%
Neuroscience 5 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 8 14%
Unknown 11 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2013.
All research outputs
#18,300,116
of 22,656,971 outputs
Outputs from BMC Neuroscience
#878
of 1,240 outputs
Outputs of similar age
#115,818
of 141,188 outputs
Outputs of similar age from BMC Neuroscience
#13
of 16 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,240 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 141,188 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.