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Neuromelanin is an immune stimulator for dendritic cells in vitro

Overview of attention for article published in BMC Neuroscience, November 2011
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Title
Neuromelanin is an immune stimulator for dendritic cells in vitro
Published in
BMC Neuroscience, November 2011
DOI 10.1186/1471-2202-12-116
Pubmed ID
Authors

Uwe Oberländer, Katrien Pletinckx, Anja Döhler, Nora Müller, Manfred B Lutz, Thomas Arzberger, Peter Riederer, Manfred Gerlach, Eleni Koutsilieri, Carsten Scheller

Abstract

Parkinson's disease (PD) is characterized at the cellular level by a destruction of neuromelanin (NM)-containing dopaminergic cells and a profound reduction in striatal dopamine. It has been shown recently that anti-melanin antibodies are increased in sera of Parkinson patients, suggesting that NM may act as an autoantigen. In this study we tested whether NM is being recognized by dendritic cells (DCs), the major cell type for inducing T- and B-cell responses in vivo. This recognition of NM by DCs is a prerequisite to trigger an adaptive autoimmune response directed against NM-associated structures.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Luxembourg 1 2%
Unknown 51 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 23%
Student > Master 10 19%
Researcher 6 12%
Student > Bachelor 5 10%
Student > Doctoral Student 4 8%
Other 8 15%
Unknown 7 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 25%
Medicine and Dentistry 9 17%
Biochemistry, Genetics and Molecular Biology 8 15%
Neuroscience 5 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 7 13%
Unknown 8 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2013.
All research outputs
#9,905,488
of 12,372,276 outputs
Outputs from BMC Neuroscience
#693
of 993 outputs
Outputs of similar age
#80,127
of 104,253 outputs
Outputs of similar age from BMC Neuroscience
#3
of 5 outputs
Altmetric has tracked 12,372,276 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 993 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,253 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.