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Pharmaceutical stability of colloidal saccharated iron oxide injection in normal saline

Overview of attention for article published in Journal of Pharmaceutical Health Care and Sciences, July 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 112)
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

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49 tweeters

Citations

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6 Dimensions

Readers on

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9 Mendeley
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Title
Pharmaceutical stability of colloidal saccharated iron oxide injection in normal saline
Published in
Journal of Pharmaceutical Health Care and Sciences, July 2018
DOI 10.1186/s40780-018-0116-0
Pubmed ID
Authors

Daiki Hira, Asami Suzuki, Yusuke Kono, Kosuke Shimokawa, Serika Matsuoka, Ken-yuh Hasumoto, Hiroyuki Kawahara, Masahide Onoue, Takuya Fujita, Tomonobu Okano, Mikio Kakumoto

Abstract

Colloidal saccharated iron oxide injection is used for the treatment of iron deficiency anemia in patients with a poor oral intake. Because of the poor stability of the colloid particle, there have been concerns regarding its compatibility with various injections in clinical practice. To assess the stability of colloidal saccharated iron oxide in normal saline as a diluent, pharmaceutical stability analyses were conducted using various concentrations of glucose and sodium chloride (NaCl). Colloidal saccharated iron oxide injection was diluted in three different diluents (5% glucose solution, normal saline, and 10% NaCl solution), and its appearance, colloid particle diameter, and pH were assessed. Free iron ions, which cause adverse effects, such as nausea and vomiting, were separated from the colloid particle using a dialysis membrane for 24 h, and their concentration was determined. No difference in the appearance, colloid diameter, and free iron ion fraction was observed after dilution in 5% glucose solution and normal saline. Conversely, an increased colloid aggregation and iron ion release were observed after dilution in 10% NaCl solution. Although iron colloid is unstable in acidic conditions (pH 4.0-6.0), normal diluents such as 5% glucose and normal saline did not cause colloid destabilization by pH change (pH > 8.0). Normal saline may be used as a diluent of colloidal saccharated iron oxide injection as well as glucose solution, which is recommended by the pharmaceutical company. Therefore, normal saline can be used as a diluent of colloidal saccharated iron oxide injection in patients with an underlying disease, such as diabetes mellitus, who are difficult to use glucose solution as a diluent.

Twitter Demographics

The data shown below were collected from the profiles of 49 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 22%
Professor 1 11%
Student > Bachelor 1 11%
Student > Ph. D. Student 1 11%
Researcher 1 11%
Other 0 0%
Unknown 3 33%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 4 44%
Chemistry 1 11%
Medicine and Dentistry 1 11%
Unknown 3 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2021.
All research outputs
#794,431
of 19,404,461 outputs
Outputs from Journal of Pharmaceutical Health Care and Sciences
#2
of 112 outputs
Outputs of similar age
#20,738
of 293,125 outputs
Outputs of similar age from Journal of Pharmaceutical Health Care and Sciences
#1
of 1 outputs
Altmetric has tracked 19,404,461 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 112 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,125 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them