Title |
Broadly neutralizing antibodies: What is needed to move from a rare event in HIV-1 infection to vaccine efficacy?
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Published in |
Retrovirology, July 2018
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DOI | 10.1186/s12977-018-0433-2 |
Pubmed ID | |
Authors |
Harini Subbaraman, Merle Schanz, Alexandra Trkola |
Abstract |
The elicitation of broadly neutralizing antibodies (bnAbs) is considered crucial for an effective, preventive HIV-1 vaccine. Led by the discovery of a new generation of potent bnAbs, the field has significantly advanced over the past decade. There is a wealth of knowledge about the development of bnAbs in natural infection, their specificity, potency, breadth and function. Yet, devising immunogens and vaccination regimens that evoke bnAb responses has not been successful. Where are the roadblocks in their development? What can we learn from natural infection, where bnAb induction is possible but rare? Herein, we will reflect on key discoveries and discuss open questions that may bear crucial insights needed to move towards creating effective bnAb vaccines. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 27% |
Switzerland | 2 | 18% |
Kenya | 1 | 9% |
Australia | 1 | 9% |
United Kingdom | 1 | 9% |
Unknown | 3 | 27% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 45% |
Science communicators (journalists, bloggers, editors) | 3 | 27% |
Scientists | 2 | 18% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 84 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 23% |
Student > Master | 11 | 13% |
Researcher | 10 | 12% |
Student > Doctoral Student | 6 | 7% |
Student > Bachelor | 5 | 6% |
Other | 8 | 10% |
Unknown | 25 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 23 | 27% |
Biochemistry, Genetics and Molecular Biology | 21 | 25% |
Agricultural and Biological Sciences | 9 | 11% |
Medicine and Dentistry | 2 | 2% |
Unspecified | 1 | 1% |
Other | 2 | 2% |
Unknown | 26 | 31% |