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Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder

Overview of attention for article published in Molecular Autism, October 2015
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  • Average Attention Score compared to outputs of the same age and source

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7 X users

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36 Dimensions

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68 Mendeley
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Title
Insistence on sameness relates to increased covariance of gray matter structure in autism spectrum disorder
Published in
Molecular Autism, October 2015
DOI 10.1186/s13229-015-0047-7
Pubmed ID
Authors

Ian W. Eisenberg, Gregory L. Wallace, Lauren Kenworthy, Stephen J. Gotts, Alex Martin

Abstract

Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavior (RRB), a core component of ASD. Behavioral studies have identified insistence on sameness (IS) as a separable RRB dimension prominent in high-functioning ASD, though no simple brain-behavior relationship has emerged. Structural covariance, a measure of morphological coupling among brain regions using magnetic resonance imaging (MRI), has proven an informative measure of anatomical relationships in typical development and neurodevelopmental disorders. In this study, we use this measure to characterize the relationship between brain structure and IS. We quantified the structural covariance of cortical and subcortical gray matter volume in 55 individuals with high-functioning ASD using 3T MRI. We then related these structural metrics to individual IS scores, as assessed by the Repetitive Behavior Scale-Revised (RBS-R). We found that increased coupling among subcortical regions and between subcortical and cortical regions related to greater IS symptom severity. Most pronounced, the striatum and amygdala participated in a plurality of identified relationships, indicating a central role for these structures in IS symptomatology. These structural associations were specific to IS and did not relate to any of the other RRB subcomponents measured by the RBS-R. This study indicates that behavioral dimensions in ASD can relate to the coordination of development across multiple brain regions, which might be otherwise obscured using typical brain-behavior correlations. It also expands the structures traditionally related to RRB in ASD and provides neuroanatomical evidence supportive of IS as a separate RRB dimension. ClinicalTrials.gov NCT01031407.

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The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 68 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 16%
Student > Bachelor 11 16%
Researcher 9 13%
Student > Master 9 13%
Student > Doctoral Student 4 6%
Other 8 12%
Unknown 16 24%
Readers by discipline Count As %
Psychology 20 29%
Neuroscience 5 7%
Agricultural and Biological Sciences 3 4%
Nursing and Health Professions 3 4%
Medicine and Dentistry 3 4%
Other 9 13%
Unknown 25 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2015.
All research outputs
#6,108,465
of 22,829,683 outputs
Outputs from Molecular Autism
#423
of 669 outputs
Outputs of similar age
#73,717
of 274,923 outputs
Outputs of similar age from Molecular Autism
#10
of 15 outputs
Altmetric has tracked 22,829,683 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.3. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,923 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.