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Antioxidant and cytotoxic activities of three species of tropical seaweeds

Overview of attention for article published in BMC Complementary and Alternative Medicine, September 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

twitter
1 tweeter
peer_reviews
1 peer review site

Citations

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26 Dimensions

Readers on

mendeley
108 Mendeley
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Title
Antioxidant and cytotoxic activities of three species of tropical seaweeds
Published in
BMC Complementary and Alternative Medicine, September 2015
DOI 10.1186/s12906-015-0867-1
Pubmed ID
Authors

Yin Yin Chia, M S Kanthimathi, Kong Soo Khoo, Jayakumar Rajarajeswaran, Hwee Ming Cheng, Wai Sum Yap

Abstract

Three species of seaweeds (Padina tetrastromatica, Caulerpa racemosa and Turbinaria ornata) are widely consumed by Asians as nutraceutical food due to their antioxidant properties. Studies have shown that these seaweeds exhibit bioactivities which include antimicrobial, antiviral, anti-hypertensive and anticoagulant activities. However, investigations into the mechanisms of action pertaining to the cytotoxic activity of the seaweeds are limited. The aim of this study was to determine the antioxidant and cytotoxic activities of whole extracts of P. tetrastromatica, C. racemosa and T. ornata, including the cellular events leading to the apoptotic cell death of the extract treated-MCF-7 cells. Bioassay guided fractionation was carried out and the compounds identified. Powdered samples were sequentially extracted for 24 h. Their antioxidant activities were assessed by the DPPH radical, superoxide, nitric oxide and hydroxyl radical scavenging assays. The cytotoxic activity of the extract-treated MCF-7cells was assessed using the MTT assay. The most potent fraction was subjected to bioassay guided fractionation with column chromatography. All the fractions were tested for cytotoxic activity, caspase activity and effect on DNA fragmentation. All three seaweeds showed potent radical scavenging activities in the various assays. The activity of the cellular antioxidant enzymes, superoxide dismutase, catalase and glutathione reductase, in MCF-7 cells, decreased in a time-dependent manner. The partially purified fractions exhibited higher cytotoxic activity, as assessed by the MTT assay, than the whole extracts in the breast adenocarcinoma cell line, MCF-7. LC-MS analysis revealed the presence of bioactive alkaloids such as camptothecin, lycodine and pesudopelletierine. Based on the results obtained, all three seaweeds are rich sources of enzymatic and non-enzymatic antioxidants which could contribute to their reported medicinal benefits.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 <1%
Unknown 107 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 22 20%
Student > Ph. D. Student 14 13%
Researcher 9 8%
Student > Master 8 7%
Lecturer > Senior Lecturer 5 5%
Other 20 19%
Unknown 30 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 26%
Pharmacology, Toxicology and Pharmaceutical Science 12 11%
Medicine and Dentistry 8 7%
Chemistry 5 5%
Biochemistry, Genetics and Molecular Biology 5 5%
Other 15 14%
Unknown 35 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2016.
All research outputs
#3,357,679
of 7,896,890 outputs
Outputs from BMC Complementary and Alternative Medicine
#777
of 1,973 outputs
Outputs of similar age
#88,976
of 239,238 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#24
of 71 outputs
Altmetric has tracked 7,896,890 research outputs across all sources so far. This one has received more attention than most of these and is in the 56th percentile.
So far Altmetric has tracked 1,973 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,238 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.