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Functional development of the adult ovine mammary gland—insights from gene expression profiling

Overview of attention for article published in BMC Genomics, October 2015
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  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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4 tweeters

Citations

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35 Dimensions

Readers on

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49 Mendeley
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Title
Functional development of the adult ovine mammary gland—insights from gene expression profiling
Published in
BMC Genomics, October 2015
DOI 10.1186/s12864-015-1947-9
Pubmed ID
Authors

Amy M Paten, Elizabeth J Duncan, Sarah J Pain, Sam W Peterson, Paul R Kenyon, Hugh T Blair, Peter K Dearden

Abstract

The mammary gland is a dynamic organ that undergoes dramatic physiological adaptations during the transition from late pregnancy to lactation. Investigation of the molecular basis of mammary development and function will provide fundamental insights into tissue remodelling as well as a better understanding of milk production and mammary disease. This is important to livestock production systems and human health. Here we use RNA-seq to identify differences in gene expression in the ovine mammary gland between late pregnancy and lactation. Between late pregnancy (135 days of gestation ± 2.4 SD) and lactation (15 days post partum ± 1.27 SD) 13 % of genes in the sheep genome were differentially expressed in the ovine mammary gland. In late pregnancy, cell proliferation, beta-oxidation of fatty acids and translation were identified as key biological processes. During lactation, high levels of milk fat synthesis were mirrored by enrichment of genes associated with fatty acid biosynthesis, transport and lipogenesis. Protein processing in the endoplasmic reticulum was enriched during lactation, likely in support of active milk protein synthesis. Hormone and growth factor signalling and activation of signal transduction pathways, including the JAK-STAT and PPAR pathways, were also differently regulated, indicating key roles for these pathways in functional development of the ovine mammary gland. Changes in the expression of epigenetic regulators, particularly chromatin remodellers, indicate a possible role in coordinating the large-scale transcriptional changes that appear to be required to switch mammary processes from growth and development during late pregnancy to synthesis and secretion of milk during lactation. Coordinated transcriptional regulation of large numbers of genes is required to switch between mammary tissue establishment during late pregnancy, and activation and maintenance of milk production during lactation. Our findings indicate the remarkable plasticity of the mammary gland, and the coordinated regulation of multiple genes and pathways to begin milk production. Genes and pathways identified by the present study may be important for managing milk production and mammary development, and may inform studies of diseases affecting the mammary gland.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
New Zealand 1 2%
Unknown 48 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 18%
Student > Master 8 16%
Student > Ph. D. Student 6 12%
Professor > Associate Professor 3 6%
Professor 3 6%
Other 8 16%
Unknown 12 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 37%
Medicine and Dentistry 6 12%
Biochemistry, Genetics and Molecular Biology 4 8%
Veterinary Science and Veterinary Medicine 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 8%
Unknown 14 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2015.
All research outputs
#6,682,605
of 12,378,687 outputs
Outputs from BMC Genomics
#3,352
of 7,251 outputs
Outputs of similar age
#99,629
of 257,172 outputs
Outputs of similar age from BMC Genomics
#156
of 344 outputs
Altmetric has tracked 12,378,687 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,251 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,172 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 344 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.