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Improving gene expression data interpretation by finding latent factors that co-regulate gene modules with clinical factors

Overview of attention for article published in BMC Genomics, November 2011
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Title
Improving gene expression data interpretation by finding latent factors that co-regulate gene modules with clinical factors
Published in
BMC Genomics, November 2011
DOI 10.1186/1471-2164-12-563
Pubmed ID
Authors

Tianwei Yu, Yun Bai

Abstract

In the analysis of high-throughput data with a clinical outcome, researchers mostly focus on genes/proteins that show first-order relations with the clinical outcome. While this approach yields biomarkers and biological mechanisms that are easily interpretable, it may miss information that is important to the understanding of disease mechanism and/or treatment response. Here we test the hypothesis that unobserved factors can be mobilized by the living system to coordinate the response to the clinical factors.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 14%
France 1 7%
Unknown 11 79%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 50%
Professor > Associate Professor 2 14%
Professor 1 7%
Student > Ph. D. Student 1 7%
Student > Bachelor 1 7%
Other 0 0%
Unknown 2 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 36%
Medicine and Dentistry 4 29%
Biochemistry, Genetics and Molecular Biology 2 14%
Unknown 3 21%