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Indomethacin induced gene regulation in the rat hippocampus

Overview of attention for article published in Molecular Brain, October 2015
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Title
Indomethacin induced gene regulation in the rat hippocampus
Published in
Molecular Brain, October 2015
DOI 10.1186/s13041-015-0150-x
Pubmed ID
Authors

Monica Sathyanesan, Matthew J. Girgenti, Jennifer Warner-Schmidt, Samuel S. Newton

Abstract

Non-steroidal anti-inflammatory drugs such as indomethacin are widely used to treat inflammatory diseases and manage pain, fever and inflammation in several conditions, including neuropsychiatric disorders. Although they predominantly function by inhibiting cyclooxygenase (COX) activity, important COX-independent actions also occur. These actions could be responsible for the adverse side effects associated with chronic and/or high dose usage of this popular drug class. We examined gene regulation in the hippocampus after peripheral administration of indomethacin by employing a microarray approach. Secondary confirmation and the brain expression pattern of regulated genes was examined by in situ hybridization and immunohistochemistry. Transglutaminase 2, serum glucocorticoid inducible kinase, Inhibitor of NF-kappa B and vascular endothelial growth factor were among genes that were prominently upregulated, while G-protein coupled receptor 56 and neuropeptide Y were among genes that were downregulated by indomethacin. Co-localization studies using blood vessel markers revealed that transglutaminase 2 was induced specifically in brain vasculature. The data demonstrate that COX-inhibitors can differentially regulate gene transcription in multiple, functionally distinctly cell types in the brain. The results provide additional insight into the molecular actions of COX-inhibitors and indicate that their effects on vasculature could influence cerebral blood flow mechanisms.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 30%
Researcher 2 20%
Student > Master 1 10%
Student > Doctoral Student 1 10%
Professor > Associate Professor 1 10%
Other 0 0%
Unknown 2 20%
Readers by discipline Count As %
Neuroscience 3 30%
Medicine and Dentistry 2 20%
Agricultural and Biological Sciences 2 20%
Biochemistry, Genetics and Molecular Biology 1 10%
Unknown 2 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2015.
All research outputs
#9,144,854
of 11,426,369 outputs
Outputs from Molecular Brain
#395
of 501 outputs
Outputs of similar age
#170,099
of 247,313 outputs
Outputs of similar age from Molecular Brain
#22
of 24 outputs
Altmetric has tracked 11,426,369 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 501 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.