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Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition

Overview of attention for article published in Journal of Neuroinflammation, August 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#39 of 2,926)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

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10 news outlets
twitter
8 X users
wikipedia
1 Wikipedia page
reddit
1 Redditor
video
1 YouTube creator

Citations

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57 Dimensions

Readers on

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75 Mendeley
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Title
Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition
Published in
Journal of Neuroinflammation, August 2018
DOI 10.1186/s12974-018-1242-1
Pubmed ID
Authors

Daniel Lang, Björn H. Schott, Marco van Ham, Lorena Morton, Leonora Kulikovskaja, Rodrigo Herrera-Molina, Rainer Pielot, Frank Klawonn, Dirk Montag, Lothar Jänsch, Eckart D. Gundelfinger, Karl Heinz Smalla, Ildiko Rita Dunay

Abstract

Chronic infection with the neurotropic parasite Toxoplasma gondii has been implicated in the risk for several neuropsychiatric disorders. The mechanisms, by which the parasite may alter neural function and behavior of the host, are not yet understood completely. Here, a novel proteomic approach using mass spectrometry was employed to investigate the alterations in synaptic protein composition in a murine model of chronic toxoplasmosis. In a candidate-based strategy, immunoblot analysis and immunohistochemistry were applied to investigate the expression levels of key synaptic proteins in glutamatergic signaling. A comparison of the synaptosomal protein composition revealed distinct changes upon infection, with multiple proteins such as EAAT2, Shank3, AMPA receptor, and NMDA receptor subunits being downregulated, whereas inflammation-related proteins showed an upregulation. Treatment with the antiparasitic agent sulfadiazine strongly reduced tachyzoite levels and diminished neuroinflammatory mediators. However, in both conditions, a significant number of latent cysts persisted in the brain. Conversely, infection-related alterations of key synaptic protein levels could be partly reversed by the treatment. These results provide evidence for profound changes especially in synaptic protein composition in T. gondii-infected mice with a downregulation of pivotal components of glutamatergic neurotransmission. Our results suggest that the detected synaptic alterations are a consequence of the distinct neuroinflammatory milieu caused by the neurotropic parasite.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 75 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 17%
Student > Ph. D. Student 10 13%
Student > Doctoral Student 5 7%
Researcher 5 7%
Student > Master 5 7%
Other 10 13%
Unknown 27 36%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 13%
Medicine and Dentistry 9 12%
Agricultural and Biological Sciences 6 8%
Psychology 3 4%
Neuroscience 3 4%
Other 10 13%
Unknown 34 45%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 81. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2023.
All research outputs
#519,526
of 25,282,542 outputs
Outputs from Journal of Neuroinflammation
#39
of 2,926 outputs
Outputs of similar age
#11,147
of 337,336 outputs
Outputs of similar age from Journal of Neuroinflammation
#1
of 63 outputs
Altmetric has tracked 25,282,542 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,926 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,336 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.