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A prebiotic intervention study in children with autism spectrum disorders (ASDs)

Overview of attention for article published in Microbiome, August 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)

Mentioned by

1 news outlet
2 blogs
163 tweeters
1 patent
6 Facebook pages
1 Redditor


107 Dimensions

Readers on

404 Mendeley
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A prebiotic intervention study in children with autism spectrum disorders (ASDs)
Published in
Microbiome, August 2018
DOI 10.1186/s40168-018-0523-3
Pubmed ID

Roberta Grimaldi, Glenn R. Gibson, Jelena Vulevic, Natasa Giallourou, Josué L. Castro-Mejía, Lars H. Hansen, E. Leigh Gibson, Dennis S. Nielsen, Adele Costabile


Different dietary approaches, such as gluten and casein free diets, or the use of probiotics and prebiotics have been suggested in autistic spectrum disorders in order to reduce gastrointestinal (GI) disturbances. GI symptoms are of particular interest in this population due to prevalence and correlation with the severity of behavioural traits. Nowadays, there is lack of strong evidence about the effect of dietary interventions on these problems, particularly prebiotics. Therefore, we assessed the impact of exclusion diets and a 6-week Bimuno® galactooligosaccharide (B-GOS®) prebiotic intervention in 30 autistic children. The results showed that children on exclusion diets reported significantly lower scores of abdominal pain and bowel movement, as well as lower abundance of Bifidobacterium spp. and Veillonellaceae family, but higher presence of Faecalibacterium prausnitzii and Bacteroides spp. In addition, significant correlations were found between bacterial populations and faecal amino acids in this group, compared to children following an unrestricted diet. Following B-GOS® intervention, we observed improvements in anti-social behaviour, significant increase of Lachnospiraceae family, and significant changes in faecal and urine metabolites. To our knowledge, this is the first study where the effect of exclusion diets and prebiotics has been evaluated in autism, showing potential beneficial effects. A combined dietary approach resulted in significant changes in gut microbiota composition and metabolism suggesting that multiple interventions might be more relevant for the improvement of these aspects as well as psychological traits. NCT02720900 ; registered in November 2015.

Twitter Demographics

The data shown below were collected from the profiles of 163 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 404 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 404 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 78 19%
Student > Master 53 13%
Researcher 40 10%
Student > Ph. D. Student 38 9%
Student > Doctoral Student 26 6%
Other 67 17%
Unknown 102 25%
Readers by discipline Count As %
Medicine and Dentistry 76 19%
Biochemistry, Genetics and Molecular Biology 41 10%
Nursing and Health Professions 35 9%
Agricultural and Biological Sciences 29 7%
Neuroscience 26 6%
Other 76 19%
Unknown 121 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 123. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2021.
All research outputs
of 19,171,602 outputs
Outputs from Microbiome
of 1,158 outputs
Outputs of similar age
of 291,832 outputs
Outputs of similar age from Microbiome
of 1 outputs
Altmetric has tracked 19,171,602 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,158 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,832 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them