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Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults

Overview of attention for article published in BMC Obesity, October 2015
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
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Title
Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults
Published in
BMC Obesity, October 2015
DOI 10.1186/s40608-015-0070-4
Pubmed ID
Authors

Manish S. Bharadwaj, Daniel J. Tyrrell, Iris Leng, Jamehl L. Demons, Mary F. Lyles, J. Jeffrey Carr, Barbara J. Nicklas, Anthony J. A. Molina

Abstract

Mitochondrial function declines with age; however, the relationship between adiposity and mitochondrial function among older adults is unclear. This study examined relationships between skeletal muscle mitochondrial content and electron transport chain complex 2 driven respiration with whole body and thigh composition, body fat distribution, and insulin sensitivity in older adults. 25 healthy, sedentary, weight-stable men (N = 13) and women (N = 12) >65 years of age, with a BMI range of 18-35 kg/m(2), participated in this study. Vastus lateralis biopsies were analyzed for citrate synthase (CS) activity and succinate mediated respiration of isolated mitochondria. Whole body and thigh composition were measured by DXA and CT. HOMA-IR was calculated using fasting glucose and insulin as an estimate of insulin sensitivity. Similar to reports in middle-aged adults, skeletal muscle CS activity was negatively correlated with BMI (R = -0.43) in our cohort of older adults. Higher total and thigh adiposity were correlated with lower CS activity independent of BMI (R = -0.50 and -0.71 respectively). Maximal complex 2 driven mitochondrial respiration was negatively correlated with lower body adiposity in males (R = -0.66). In this cohort of non-diabetic older adults, both HOMA-IR and insulin were positively correlated with CS activity when controlling for BMI (R = 0.57 and 0.66 respectively). Adiposity and body composition are correlated with skeletal muscle mitochondrial content and electron transport chain function in healthy, sedentary, community dwelling, older adults. Specific relationships of mitochondrial bioenergetics with gender and insulin sensitivity are also apparent. ClinicalTrials.gov identifier NCT01049698.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Unknown 57 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 19%
Student > Doctoral Student 7 12%
Student > Ph. D. Student 7 12%
Researcher 7 12%
Professor > Associate Professor 3 5%
Other 8 14%
Unknown 15 26%
Readers by discipline Count As %
Medicine and Dentistry 10 17%
Nursing and Health Professions 9 16%
Biochemistry, Genetics and Molecular Biology 7 12%
Sports and Recreations 5 9%
Agricultural and Biological Sciences 2 3%
Other 9 16%
Unknown 16 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2015.
All research outputs
#14,027,062
of 23,881,329 outputs
Outputs from BMC Obesity
#104
of 179 outputs
Outputs of similar age
#133,664
of 280,557 outputs
Outputs of similar age from BMC Obesity
#6
of 9 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 179 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,557 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.