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Microbial communities and inflammatory response in the endometrium differ between normal and metritic dairy cows at 5–10 days post-partum

Overview of attention for article published in Veterinary Research, August 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)

Mentioned by

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7 tweeters

Citations

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21 Dimensions

Readers on

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45 Mendeley
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Title
Microbial communities and inflammatory response in the endometrium differ between normal and metritic dairy cows at 5–10 days post-partum
Published in
Veterinary Research, August 2018
DOI 10.1186/s13567-018-0570-6
Pubmed ID
Authors

Ron Sicsic, Tamir Goshen, Rahul Dutta, Noa Kedem-Vaanunu, Veronica Kaplan-Shabtai, Zohar Pasternak, Yuval Gottlieb, Nahum Y. Shpigel, Tal Raz

Abstract

Post-partum metritis is among the most prevalent disease in dairy cows affecting animal welfare and inflicting considerable economic loses. While post-partum contamination of the uterus is rife in dairy cows, only a fraction of these animals will develop metritis. Our main objective was to compare the bacterial communities and the inflammatory response in the endometrium of healthy and metritic dairy cows. Holstein-Friesian cows (n = 35) were sampled immediately following clinical classification as healthy (n = 21), suffering from metritis (n = 13) or septic metritis (n = 1), based on veterinary examination at 5-10 days post-partum. Polymorphonuclear cells (PMN) percentage in endometrial cytology was significantly higher in cows with metritis. Full-thickness uterine biopsy analysis revealed that the luminal epithelium in inter-caruncle areas was preserved in healthy cows, but in metritis it was compromised, with marked PMN infiltration particularly in the apical endometrium. Gram staining revealed that bacterial load and spatial distribution was associated with disease severity. 16S-rDNA bacterial community analysis revealed unique endometrial bacterial community composition in metritic cows, as compared to more diverse communities among healthy cows. The most abundant phyla in healthy cows were Proteobacteria (31.8 ± 9.3%), Firmicutes (27.9 ± 8.4%) and Bacteroidetes (19.7 ± 7.2%), while Bacteroidetes (60.3 ± 10.3%), Fusobacteria (13.4 ± 5.9%) and Firmicutes (10.5 ± 3.3%) were most abundant in the endometrial mucosa of metritic cows. Relative abundance of Bacteroidetes (19.7 ± 7.2% vs. 60.3 ± 10.3%), Fusobacteria (7.5 ± 5.2% vs. 13.4 ± 5.9%) and Proteobacteria (31.8 ± 9.3% vs. 7.3 ± 5.6%) phyla differed significantly between healthy and metritic cows. In summary, endometrial PMN abundance, spatial distribution and bacterial communities differed between healthy and metritic dairy cows at early post-partum.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 22%
Student > Ph. D. Student 5 11%
Student > Bachelor 5 11%
Researcher 4 9%
Student > Doctoral Student 2 4%
Other 6 13%
Unknown 13 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 24%
Veterinary Science and Veterinary Medicine 10 22%
Medicine and Dentistry 4 9%
Biochemistry, Genetics and Molecular Biology 3 7%
Mathematics 1 2%
Other 5 11%
Unknown 11 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2018.
All research outputs
#3,845,289
of 13,813,295 outputs
Outputs from Veterinary Research
#193
of 857 outputs
Outputs of similar age
#96,499
of 273,290 outputs
Outputs of similar age from Veterinary Research
#1
of 2 outputs
Altmetric has tracked 13,813,295 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 857 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,290 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them