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The gut microbiota drives the impact of bile acids and fat source in diet on mouse metabolism

Overview of attention for article published in Microbiome, August 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 blog
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18 X users

Citations

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177 Dimensions

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265 Mendeley
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Title
The gut microbiota drives the impact of bile acids and fat source in diet on mouse metabolism
Published in
Microbiome, August 2018
DOI 10.1186/s40168-018-0510-8
Pubmed ID
Authors

Sarah Just, Stanislas Mondot, Josef Ecker, Katrin Wegner, Eva Rath, Laura Gau, Theresa Streidl, Genevieve Hery-Arnaud, Sinah Schmidt, Till Robin Lesker, Valentin Bieth, Andreas Dunkel, Till Strowig, Thomas Hofmann, Dirk Haller, Gerhard Liebisch, Philippe Gérard, Sascha Rohn, Patricia Lepage, Thomas Clavel

Abstract

As the gut microbiota contributes to metabolic health, it is important to determine specific diet-microbiota interactions that influence host metabolism. Bile acids and dietary fat source can alter phenotypes of diet-induced obesity, but the interplay with intestinal microorganisms is unclear. Here, we investigated metabolic consequences of diets enriched in primary bile acids with or without addition of lard or palm oil, and studied gut microbiota structure and functions in mice. In combination with bile acids, dietary lard fed to male C57BL/6N mice for a period of 8 weeks enhanced fat mass accumulation in colonized, but not in germ-free mice when compared to palm oil. This was associated with impaired glucose tolerance, lower fasting insulin levels, lower counts of enteroendocrine cells, fatty liver, and elevated amounts of hepatic triglycerides, cholesteryl esters, and monounsaturated fatty acids. Lard- and bile acid-fed mice were characterized by shifts in dominant gut bacterial communities, including decreased relative abundances of Lachnospiraceae and increased occurrence of Desulfovibrionaceae and the species Clostridium lactatifermentans and Flintibacter butyricus. Metatranscriptomic analysis revealed shifts in microbial functions, including lipid and amino acid metabolism. Caution is required when interpreting data from diet-induced obesity models due to varying effects of dietary fat source. Detrimental metabolic consequences of a diet enriched with lard and primary bile acids were dependent on microbial colonization of the host and were linked to hepatic lipid rearrangements and to alterations of dominant bacterial communities in the cecum.

X Demographics

X Demographics

The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 265 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 265 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 51 19%
Student > Master 42 16%
Researcher 40 15%
Student > Bachelor 19 7%
Student > Doctoral Student 12 5%
Other 30 11%
Unknown 71 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 46 17%
Agricultural and Biological Sciences 39 15%
Medicine and Dentistry 29 11%
Immunology and Microbiology 24 9%
Nursing and Health Professions 8 3%
Other 29 11%
Unknown 90 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2019.
All research outputs
#2,088,718
of 25,142,442 outputs
Outputs from Microbiome
#829
of 1,725 outputs
Outputs of similar age
#41,574
of 336,942 outputs
Outputs of similar age from Microbiome
#34
of 53 outputs
Altmetric has tracked 25,142,442 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,725 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.4. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,942 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.