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Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease

Overview of attention for article published in BMC Pulmonary Medicine, August 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (69th percentile)

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7 tweeters

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42 Mendeley
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Title
Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease
Published in
BMC Pulmonary Medicine, August 2018
DOI 10.1186/s12890-018-0697-2
Pubmed ID
Authors

Jonas K F Jakobsson, H Laura Aaltonen, Hanna Nicklasson, Anders Gudmundsson, Jenny Rissler, Per Wollmer, Jakob Löndahl

Abstract

Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of this study is to investigate the differences in lung deposition of nanoparticles in the distal lung for healthy subjects and subjects with respiratory disease. Lung deposition of nanoparticles (50 and 100 nm) was measured after a 10 s breath-hold for three groups: healthy never-smoking subjects (n = 17), asymptomatic (active and former) smokers (n = 15) and subjects with chronic obstructive pulmonary disease (n = 16). Measurements were made at 1300 mL and 1800 mL volumetric lung depth. Each subject also underwent conventional lung function tests, including post bronchodilator FEV1, VC, and diffusing capacity for carbon monoxide, DL,CO. Patients with previously diagnosed respiratory disease underwent a CT-scan of the lungs. Particle lung deposition fraction, was compared between the groups and with conventional lung function tests. We found that the deposition fraction was significantly lower for subjects with emphysema compared to the other subjects (p = 0.001-0.01), but no significant differences were found between healthy never-smokers and smokers. Furthermore, the particle deposition correlated with pulmonary function tests, FEV1%Pred (p < 0.05), FEV1/VC%Pred (p < 0.01) and DL,CO (p < 0.0005) when all subjects were included. Furthermore, for subjects with emphysema, deposition fraction correlated strongly with DL,CO (Pearson's r = 0.80-0.85, p < 0.002) while this correlation was not found within the other groups. Lower deposition fraction was observed for emphysematous subjects and this can be explained by enlarged distal airspaces in the lungs. As expected, deposition increases for smaller particles and deeper inhalation. The observed results have implications for exposure assessment of air pollution and dosimetry of aerosol-based drug delivery of nanoparticles.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 8 19%
Student > Ph. D. Student 7 17%
Student > Bachelor 5 12%
Student > Master 5 12%
Student > Doctoral Student 4 10%
Other 6 14%
Unknown 7 17%
Readers by discipline Count As %
Unspecified 8 19%
Engineering 4 10%
Nursing and Health Professions 3 7%
Chemical Engineering 3 7%
Biochemistry, Genetics and Molecular Biology 2 5%
Other 11 26%
Unknown 11 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2020.
All research outputs
#4,778,559
of 19,259,035 outputs
Outputs from BMC Pulmonary Medicine
#296
of 1,529 outputs
Outputs of similar age
#87,189
of 291,782 outputs
Outputs of similar age from BMC Pulmonary Medicine
#1
of 1 outputs
Altmetric has tracked 19,259,035 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,529 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,782 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them