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Variants Fok1 and Bsm1 on VDR are associated with the melanoma risk: evidence from the published epidemiological studies

Overview of attention for article published in BMC Genetics, February 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)

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3 tweeters

Citations

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17 Dimensions

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22 Mendeley
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Title
Variants Fok1 and Bsm1 on VDR are associated with the melanoma risk: evidence from the published epidemiological studies
Published in
BMC Genetics, February 2015
DOI 10.1186/s12863-015-0163-6
Pubmed ID
Authors

Wei Hou, Xuefeng Wan, Junwei Fan

Abstract

The vitamin D receptor (VDR) mediates the major cellular activities of vitamin D and regulates various signaling pathways implicated in cancer development and progression. VDR variants have been found associated with the risk of developing melanoma; however, previous epidemiological studies are inconsistent. We have systematically reviewed the published epidemiological literature and conducted a meta-analysis to assess associations between common VDR variants and melanoma risk. We identified 10 eligible studies that evaluated six VDR variants (Apa1, Bsm1, Cdx2, EcoRV, Fok1, and Taq1) in a total of 4,961 melanoma patients and 4,605 controls. The pooled estimates identified two variants-Fok1 and Bsm1-as significantly associated with melanoma risk, but not for the other four variants Apa1, Cdx2, EcorV and Taq1. For Fok1, the pooled OR was 1.18 (95% CI = 1.06-1.30; I(2) = 22%) for Ff vs. FF and 1.19 (95% CI = 1.01-1.41; I(2) = 0%) for ff vs. FF. The dominant genetic model suggested the allele f carriers showed an 18% (pooled OR = 1.18, 95% CI = 1.07-1.29; I(2) = 0%) increased risk for melanoma compared to homozygote FF. In contrast, the Bsm1 was found to be associated with a decreased risk for melanoma with the pooled OR was 0.85 (95% CI = 0.76-0.95; I(2) = 0%) for Bb vs. bb and 0.83 (95% CI = 0.68-1.00; I(2) = 28%) for BB vs. bb. Under the dominant genetic model, a 15% (pooled OR = 0.85, 95% CI = 0.76-0.94; I(2) = 0%) decrease of melanoma risk was found for those with BB or Bb genotype compared to those of bb genotype. The VDR variants Fok1 and Bsm1 may influence the susceptibility to developing melanoma, though further studies are needed to verify these conclusions.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 36%
Researcher 4 18%
Other 2 9%
Student > Master 2 9%
Student > Doctoral Student 1 5%
Other 2 9%
Unknown 3 14%
Readers by discipline Count As %
Medicine and Dentistry 9 41%
Biochemistry, Genetics and Molecular Biology 3 14%
Agricultural and Biological Sciences 2 9%
Unspecified 1 5%
Social Sciences 1 5%
Other 1 5%
Unknown 5 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2015.
All research outputs
#6,983,267
of 12,372,276 outputs
Outputs from BMC Genetics
#336
of 828 outputs
Outputs of similar age
#106,786
of 253,338 outputs
Outputs of similar age from BMC Genetics
#1
of 2 outputs
Altmetric has tracked 12,372,276 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 828 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,338 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them