Title |
Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options
|
---|---|
Published in |
Journal of Hematology & Oncology, March 2011
|
DOI | 10.1186/1756-8722-4-10 |
Pubmed ID | |
Authors |
Gerhard J Molderings, Stefan Brettner, Jürgen Homann, Lawrence B Afrin |
Abstract |
Mast cell activation disease comprises disorders characterized by accumulation of genetically altered mast cells and/or abnormal release of these cells' mediators, affecting functions in potentially every organ system, often without causing abnormalities in routine laboratory or radiologic testing. In most cases of mast cell activation disease, diagnosis is possible by relatively non-invasive investigation. Effective therapy often consists simply of antihistamines and mast cell membrane-stabilising compounds supplemented with medications targeted at specific symptoms and complications. Mast cell activation disease is now appreciated to likely be considerably prevalent and thus should be considered routinely in the differential diagnosis of patients with chronic multisystem polymorbidity or patients in whom a definitively diagnosed major illness does not well account for the entirety of the patient's presentation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 21 | 28% |
United Kingdom | 11 | 14% |
Canada | 3 | 4% |
Germany | 1 | 1% |
Ireland | 1 | 1% |
France | 1 | 1% |
Latvia | 1 | 1% |
Ecuador | 1 | 1% |
Switzerland | 1 | 1% |
Other | 0 | 0% |
Unknown | 35 | 46% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 64 | 84% |
Scientists | 5 | 7% |
Science communicators (journalists, bloggers, editors) | 3 | 4% |
Practitioners (doctors, other healthcare professionals) | 3 | 4% |
Unknown | 1 | 1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 2% |
Brazil | 1 | <1% |
Costa Rica | 1 | <1% |
Finland | 1 | <1% |
Japan | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 205 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 33 | 15% |
Other | 31 | 14% |
Researcher | 28 | 13% |
Student > Master | 28 | 13% |
Student > Ph. D. Student | 18 | 8% |
Other | 43 | 20% |
Unknown | 33 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 91 | 43% |
Agricultural and Biological Sciences | 22 | 10% |
Nursing and Health Professions | 15 | 7% |
Biochemistry, Genetics and Molecular Biology | 9 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
Other | 33 | 15% |
Unknown | 37 | 17% |