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Epigenetic changes during sepsis: on your marks!

Overview of attention for article published in Critical Care, December 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Average Attention Score compared to outputs of the same age and source

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10 X users
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1 Facebook page

Citations

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11 Dimensions

Readers on

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49 Mendeley
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Title
Epigenetic changes during sepsis: on your marks!
Published in
Critical Care, December 2015
DOI 10.1186/s13054-015-1068-5
Pubmed ID
Authors

Aurélien Bataille, Pierre Galichon, Marie-Julia Ziliotis, Iman Sadia, Alexandre Hertig

Abstract

Epigenetics is the study of how cells, organs, and even individuals utilize their genes over specific periods of time, and under specific environmental constraints. Very importantly, epigenetics is now expanding into the field of medicine and hence should provide new information for the development of drugs. Bomsztyk and colleagues have detected major epigenetic changes occurring in several organs as early as 6 h after the onset of a mouse model of multiple organ dysfunction syndrome induced by Staphylococcus aureus lung injury. Decrease in mRNA of key genes involved in endothelial function was found to be associated with (and potentially explained by) a decrease in permissive histone marks, while repressive marks were unchanged. We discuss here the limitations of a whole-organ as opposed to a cell-specific approach, the nature of the controls that were chosen, and the pitfalls of histone modifications as a cause of the eventual phenotype. While the use of 'epidrugs' is definitely welcome in the clinic, how and when they will be used in sepsis-related multiple organ dysfunction will require further experimental studies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 2%
Unknown 48 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 22%
Student > Master 9 18%
Student > Ph. D. Student 7 14%
Professor 3 6%
Student > Doctoral Student 3 6%
Other 9 18%
Unknown 7 14%
Readers by discipline Count As %
Medicine and Dentistry 18 37%
Biochemistry, Genetics and Molecular Biology 11 22%
Agricultural and Biological Sciences 7 14%
Immunology and Microbiology 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 2 4%
Unknown 8 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2015.
All research outputs
#6,264,736
of 25,373,627 outputs
Outputs from Critical Care
#3,603
of 6,554 outputs
Outputs of similar age
#88,605
of 395,397 outputs
Outputs of similar age from Critical Care
#305
of 466 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,397 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 466 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.