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Feifukang ameliorates pulmonary fibrosis by inhibiting JAK-STAT signaling pathway

Overview of attention for article published in BMC Complementary Medicine and Therapies, August 2018
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Title
Feifukang ameliorates pulmonary fibrosis by inhibiting JAK-STAT signaling pathway
Published in
BMC Complementary Medicine and Therapies, August 2018
DOI 10.1186/s12906-018-2297-3
Pubmed ID
Authors

Hongbo Li, Zhenkai Wang, Jie Zhang, Youlei Wang, Chen Yu, Jinjin Zhang, Xiaodong Song, Changjun Lv

Abstract

Feifukang (FFK) is a traditional Chinese medicine composed of herbs that protect lung function. However, difficulty arises regarding the clinical application of FFK due to the complex mechanism of Chinese medicines. This study aimed to investigate the efficacy of FFK and explore its targeted genes and pathways. Histopathological changes and collagen deposition were measured to evaluate the effect of FFK on bleomycin-induced pulmonary fibrosis in mice. The differentially expressed targeted genes and pathways were first screened using RNA sequencing. Then network pharmacology and other experiments were conducted to confirm RNA sequencing data. FFK treatment reduced the pathological score and collagen deposition, with a decrease in α-SMA and collagen. RNA sequencing and network pharmacology results all showed that FFK can ameliorate pulmonary fibrosis through multi-genes and multi-pathways. The targeted genes in JAK-STAT signaling pathway are some of the most notable components of these multi-genes and multi-pathways. Further experiments illustrated that FFK regulated phosphorylation of SMAD3, STAT3 and JAK1, and their co-expressed lncRNAs, which all are the important genes in JAK-STAT signaling pathway. FFK can ameliorate pulmonary fibrosis by inhibiting JAK-STAT signaling pathway and has potential therapeutic value for lung fibrosis treatment. Our study provides a new idea for the study of traditional Chinese medicine.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 12%
Student > Ph. D. Student 2 12%
Researcher 2 12%
Student > Master 2 12%
Student > Postgraduate 2 12%
Other 3 18%
Unknown 4 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 24%
Medicine and Dentistry 4 24%
Agricultural and Biological Sciences 2 12%
Immunology and Microbiology 1 6%
Nursing and Health Professions 1 6%
Other 0 0%
Unknown 5 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2018.
All research outputs
#17,987,106
of 23,099,576 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,372
of 3,658 outputs
Outputs of similar age
#238,174
of 331,391 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#31
of 57 outputs
Altmetric has tracked 23,099,576 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,658 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,391 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.