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Eukaryotic G protein-coupled receptors as descendants of prokaryotic sodium-translocating rhodopsins

Overview of attention for article published in Biology Direct, October 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Citations

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Title
Eukaryotic G protein-coupled receptors as descendants of prokaryotic sodium-translocating rhodopsins
Published in
Biology Direct, October 2015
DOI 10.1186/s13062-015-0091-4
Pubmed ID
Authors

Daria N. Shalaeva, Michael Y. Galperin, Armen Y. Mulkidjanian

Abstract

Microbial rhodopsins and G-protein coupled receptors (GPCRs, which include animal rhodopsins) are two distinct (super) families of heptahelical (7TM) membrane proteins that share obvious structural similarities but no significant sequence similarity. Comparison of the recently solved high-resolution structures of the sodium-translocating bacterial rhodopsin and various Na(+)-binding GPCRs revealed striking similarity of their sodium-binding sites. This similarity allowed us to construct a structure-guided sequence alignment for the two (super)families, which highlighted their evolutionary relatedness. Our analysis supports a common underlying molecular mechanism for both families that involves a highly conserved aromatic residue playing a pivotal role in rotation of the 6th transmembrane helix. This article was reviewed by Oded Beja, G. P. S. Raghava and L. Aravind.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 78 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 23%
Researcher 12 15%
Student > Master 12 15%
Student > Bachelor 5 6%
Student > Doctoral Student 3 4%
Other 10 13%
Unknown 19 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 30 38%
Agricultural and Biological Sciences 18 23%
Chemistry 3 4%
Neuroscience 2 3%
Computer Science 1 1%
Other 4 5%
Unknown 21 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2020.
All research outputs
#2,375,500
of 22,830,751 outputs
Outputs from Biology Direct
#104
of 487 outputs
Outputs of similar age
#35,296
of 279,238 outputs
Outputs of similar age from Biology Direct
#3
of 18 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 487 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,238 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.