Title |
Eukaryotic G protein-coupled receptors as descendants of prokaryotic sodium-translocating rhodopsins
|
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Published in |
Biology Direct, October 2015
|
DOI | 10.1186/s13062-015-0091-4 |
Pubmed ID | |
Authors |
Daria N. Shalaeva, Michael Y. Galperin, Armen Y. Mulkidjanian |
Abstract |
Microbial rhodopsins and G-protein coupled receptors (GPCRs, which include animal rhodopsins) are two distinct (super) families of heptahelical (7TM) membrane proteins that share obvious structural similarities but no significant sequence similarity. Comparison of the recently solved high-resolution structures of the sodium-translocating bacterial rhodopsin and various Na(+)-binding GPCRs revealed striking similarity of their sodium-binding sites. This similarity allowed us to construct a structure-guided sequence alignment for the two (super)families, which highlighted their evolutionary relatedness. Our analysis supports a common underlying molecular mechanism for both families that involves a highly conserved aromatic residue playing a pivotal role in rotation of the 6th transmembrane helix. This article was reviewed by Oded Beja, G. P. S. Raghava and L. Aravind. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Israel | 1 | 20% |
United States | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Unknown | 78 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 23% |
Researcher | 12 | 15% |
Student > Master | 12 | 15% |
Student > Bachelor | 5 | 6% |
Student > Doctoral Student | 3 | 4% |
Other | 10 | 13% |
Unknown | 19 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 30 | 38% |
Agricultural and Biological Sciences | 18 | 23% |
Chemistry | 3 | 4% |
Neuroscience | 2 | 3% |
Computer Science | 1 | 1% |
Other | 4 | 5% |
Unknown | 21 | 27% |