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Persistent detection of Zika virus RNA from an infant with severe microcephaly – a case report

Overview of attention for article published in BMC Infectious Diseases, August 2018
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  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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Title
Persistent detection of Zika virus RNA from an infant with severe microcephaly – a case report
Published in
BMC Infectious Diseases, August 2018
DOI 10.1186/s12879-018-3313-4
Pubmed ID
Authors

Carlos A. A. Brito, Adélia Henriques-Souza, Cynthia R. P. Soares, Priscila M. S. Castanha, Laís C. Machado, Mylena R. Pereira, Mariana C. M. Sobral, Antonio R. Lucena-Araujo, Gabriel L. Wallau, Rafael F. O. Franca

Abstract

Zika virus (ZIKV) is a recently emerged arbovirus, which infection during pregnancy is associated with a series of congenital malformations, collectively denominated Congenital Zika Syndrome (CZS). Following infection, ZIKV RNA has a median duration period of 10 days in plasma and up to 6 months in semen in immunocompetent adult individuals. Moreover, ZIKV is able to replicate and persist in fetal brains and placentas, consequently, infection is associated with pregnancy loss, albeit the pathogenic mechanisms are still unknown. Here we report a CZS case of an infant born during the ZIKV outbreak in northeast Brazil, the child presented recurrent episodes of seizures with prolonged presence of ZIKV RNA on the central nervous system (CNS) and blood. ZIKV RNA was identified and partially sequenced from a sample of cerebrospinal fluid (CSF) obtained from the infant with 6 months of life, and later from another sample after the infant completed 17 months of life. Commonly congenital infections were discarded based on STORCH (syphilis, toxoplasmosis, rubella, cytomegalovirus and herpes simplex virus) negative laboratory results. Presence of specific ZIKV antibodies on both mother and children confirmed the association of severe microcephaly and ZIKV infection, diagnosed after birth. Altogether, our data raise the possibility that CZS cases may result in prolonged viral presence, these findings could be useful for therapy and diagnostic recommendations.

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X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 107 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 20 19%
Researcher 17 16%
Student > Bachelor 13 12%
Student > Ph. D. Student 10 9%
Student > Doctoral Student 7 7%
Other 15 14%
Unknown 25 23%
Readers by discipline Count As %
Medicine and Dentistry 22 21%
Immunology and Microbiology 10 9%
Agricultural and Biological Sciences 7 7%
Biochemistry, Genetics and Molecular Biology 7 7%
Neuroscience 7 7%
Other 16 15%
Unknown 38 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2018.
All research outputs
#6,433,051
of 23,099,576 outputs
Outputs from BMC Infectious Diseases
#2,020
of 7,751 outputs
Outputs of similar age
#111,937
of 331,118 outputs
Outputs of similar age from BMC Infectious Diseases
#42
of 170 outputs
Altmetric has tracked 23,099,576 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 7,751 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,118 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 170 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.