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Identification and characterization of mushroom body neurons that regulate fat storage in Drosophila

Overview of attention for article published in Neural Development, August 2018
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Title
Identification and characterization of mushroom body neurons that regulate fat storage in Drosophila
Published in
Neural Development, August 2018
DOI 10.1186/s13064-018-0116-7
Pubmed ID
Authors

Bader Al-Anzi, Kai Zinn

Abstract

In an earlier study, we identified two neuronal populations, c673a and Fru-GAL4, that regulate fat storage in fruit flies. Both populations partially overlap with a structure in the insect brain known as the mushroom body (MB), which plays a critical role in memory formation. This overlap prompted us to examine whether the MB is also involved in fat storage homeostasis. Using a variety of transgenic agents, we selectively manipulated the neural activity of different portions of the MB and associated neurons to decipher their roles in fat storage regulation. Our data show that silencing of MB neurons that project into the α'β' lobes decreases de novo fatty acid synthesis and causes leanness, while sustained hyperactivation of the same neurons causes overfeeding and produces obesity. The α'β' neurons oppose and dominate the fat regulating functions of the c673a and Fru-GAL4 neurons. We also show that MB neurons that project into the γ lobe also regulate fat storage, probably because they are a subset of the Fru neurons. We were able to identify input and output neurons whose activity affects fat storage, feeding, and metabolism. The activity of cholinergic output neurons that innervating the β'2 compartment (MBON-β'2mp and MBON-γ5β'2a) regulates food consumption, while glutamatergic output neurons innervating α' compartments (MBON-γ2α'1 and MBON-α'2) control fat metabolism. We identified a new fat storage regulating center, the α'β' lobes of the MB. We also delineated the neuronal circuits involved in the actions of the α'β' lobes, and showed that food intake and fat metabolism are controlled by separate sets of postsynaptic neurons that are segregated into different output pathways.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 49 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 41%
Researcher 7 14%
Student > Bachelor 4 8%
Professor 3 6%
Student > Postgraduate 2 4%
Other 5 10%
Unknown 8 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 31%
Neuroscience 11 22%
Biochemistry, Genetics and Molecular Biology 6 12%
Immunology and Microbiology 2 4%
Nursing and Health Professions 1 2%
Other 4 8%
Unknown 10 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2018.
All research outputs
#15,330,390
of 23,577,654 outputs
Outputs from Neural Development
#119
of 227 outputs
Outputs of similar age
#200,084
of 331,745 outputs
Outputs of similar age from Neural Development
#6
of 10 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 227 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,745 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.