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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CRISPR-SKIP: programmable gene splicing with single base editors
|
|---|---|
| Published in |
Genome Biology, August 2018
|
| DOI | 10.1186/s13059-018-1482-5 |
| Pubmed ID | |
| Authors |
Michael Gapinske, Alan Luu, Jackson Winter, Wendy S. Woods, Kurt A. Kostan, Nikhil Shiva, Jun S. Song, Pablo Perez-Pinera |
| Abstract |
CRISPR gene editing has revolutionized biomedicine and biotechnology by providing a simple means to engineer genes through targeted double-strand breaks in the genomic DNA of living cells. However, given the stochasticity of cellular DNA repair mechanisms and the potential for off-target mutations, technologies capable of introducing targeted changes with increased precision, such as single-base editors, are preferred. We present a versatile method termed CRISPR-SKIP that utilizes cytidine deaminase single-base editors to program exon skipping by mutating target DNA bases within splice acceptor sites. Given its simplicity and precision, CRISPR-SKIP will be broadly applicable in gene therapy and synthetic biology. |
X Demographics
The data shown below were collected from the profiles of 75 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 20 | 27% |
| United Kingdom | 7 | 9% |
| Australia | 4 | 5% |
| Germany | 4 | 5% |
| Switzerland | 3 | 4% |
| Canada | 3 | 4% |
| Spain | 3 | 4% |
| France | 2 | 3% |
| Comoros | 1 | 1% |
| Other | 6 | 8% |
| Unknown | 22 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 44 | 59% |
| Scientists | 25 | 33% |
| Practitioners (doctors, other healthcare professionals) | 5 | 7% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 311 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 311 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 68 | 22% |
| Researcher | 51 | 16% |
| Student > Bachelor | 36 | 12% |
| Student > Master | 24 | 8% |
| Student > Doctoral Student | 13 | 4% |
| Other | 42 | 14% |
| Unknown | 77 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 107 | 34% |
| Agricultural and Biological Sciences | 63 | 20% |
| Medicine and Dentistry | 12 | 4% |
| Immunology and Microbiology | 8 | 3% |
| Neuroscience | 8 | 3% |
| Other | 27 | 9% |
| Unknown | 86 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 192. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2024.
All research outputs
#209,160
of 25,584,565 outputs
Outputs from Genome Biology
#65
of 4,492 outputs
Outputs of similar age
#4,301
of 341,086 outputs
Outputs of similar age from Genome Biology
#5
of 67 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,492 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,086 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.