Title |
Xanthorrhizol: a review of its pharmacological activities and anticancer properties
|
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Published in |
Cancer Cell International, October 2015
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DOI | 10.1186/s12935-015-0255-4 |
Pubmed ID | |
Authors |
Seok Fang Oon, Meenakshii Nallappan, Thiam Tsui Tee, Shamarina Shohaimi, Nur Kartinee Kassim, Mohd Shazrul Fazry Sa’ariwijaya, Yew Hoong Cheah |
Abstract |
Xanthorrhizol (XNT) is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza Roxb. It has been well established to possess a variety of biological activities such as anticancer, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, antihypertensive, antiplatelet, nephroprotective, hepatoprotective, estrogenic and anti-estrogenic effects. Since many synthetic drugs possess toxic side effects and are unable to support the increasing prevalence of disease, there is significant interest in developing natural product as new therapeutics. XNT is a very potent natural bioactive compound that could fulfil the current need for new drug discovery. Despite its importance, a comprehensive review of XNT's pharmacological activities has not been published in the scientific literature to date. Here, the present review aims to summarize the available information in this area, focus on its anticancer properties and indicate the current status of the research. This helps to facilitate the understanding of XNT's pharmacological role in drug discovery, thus suggesting areas where further research is required. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Indonesia | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Malaysia | 1 | <1% |
Spain | 1 | <1% |
Italy | 1 | <1% |
Unknown | 356 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 91 | 25% |
Student > Master | 31 | 9% |
Researcher | 21 | 6% |
Student > Ph. D. Student | 17 | 5% |
Lecturer | 15 | 4% |
Other | 31 | 9% |
Unknown | 153 | 43% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 58 | 16% |
Medicine and Dentistry | 44 | 12% |
Biochemistry, Genetics and Molecular Biology | 25 | 7% |
Agricultural and Biological Sciences | 22 | 6% |
Chemistry | 21 | 6% |
Other | 34 | 9% |
Unknown | 155 | 43% |