@GermHunterMD @annieluet Yes 👏 Many #unbalanced RCTs are practice-changing. Why 2:1 randomization ?🤷🏻♂️ While STI is not deadly and ATB resistance is of concern, I always wonder if less control poses ethical issues Re: equipoise. If interested, more
RT @charlesweijer: Is #unbalanced #randomization in #RCTs ethical? A clinical vignette-based #survey of #IRB members (open access) by Clari…
治験審査委員会のメンバーでどんな理由があろうと不均等ランダム化は正当化できないという人が39.2%、コストさえ許せば許容できるという人が31.1%、方法論や安全性には問題がないが、コストや倫理的問題があると考える人が29.7%。Heterogeneous perception of the ethical … https://t.co/u3oxaiaWae
#IRB members have mixed opinions of unbalanced randomized #clinicaltrial design: some do not think it obeys the necessary principle of #equipoise and are therefore #unethical: https://t.co/Jwud2la6bv