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Determining the HPV vaccine schedule for a HIV-infected population in sub Saharan Africa, a commentary

Overview of attention for article published in Virology Journal, August 2018
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Title
Determining the HPV vaccine schedule for a HIV-infected population in sub Saharan Africa, a commentary
Published in
Virology Journal, August 2018
DOI 10.1186/s12985-018-1039-y
Pubmed ID
Authors

Sonia Menon, Rodolfo Rossi, Mbabazi Kariisa, Steven Callens

Abstract

Epidemiological studies have established human papillomavirus (HPV) infection as the central cause of invasive cervical cancer (ICC) and its precursor lesions. HIV is associated with a higher prevalence and persistence of a broader range of high-risk HPV genotypes, which in turn results in a higher risk of cervical disease. Recent WHO HPV vaccination schedule recommendations, along with the roll out of HAART at an earlier CD4 count within the female HIV-infected population, may have programmatic implications for sub Saharan Africa. This communication identifies research areas, which will need to be addressed for determining a HPV vaccine schedule for this population in sub Saharan Africa. A review of WHO latest recommendations and the evidence concerning one-dose HPV vaccine schedules was undertaken. For females ≥15 years at the time of first dose and immunocompromised and/or HIV-infected, a 3-dose schedule (0, 1-2, 6 months) is recommended for all three vaccines. There is some evidence that there is similar protection against HPV 16 and 18 infection from a single vaccination than from two or three doses, however there is no cross protection conferred to other genotypes. There is a need for periodic prevalence studies to determine the vaccination coverage of bivalent, quadrivalent and nonavalent vaccine targeted oncogenic HPV genotypes in women with CIN 3 or ICC at national level. In light of the increasing number of sub Saharan HIV-infected girls initiating HAART at a CD4 count above 350 mm3, there are a number of clinical, virological and public health research gaps to address before a tailored vaccine schedule can be established for this population.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 76 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 20%
Researcher 8 11%
Student > Ph. D. Student 8 11%
Student > Bachelor 6 8%
Lecturer 3 4%
Other 6 8%
Unknown 30 39%
Readers by discipline Count As %
Nursing and Health Professions 14 18%
Medicine and Dentistry 13 17%
Biochemistry, Genetics and Molecular Biology 3 4%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Immunology and Microbiology 3 4%
Other 6 8%
Unknown 34 45%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2019.
All research outputs
#15,543,612
of 23,100,534 outputs
Outputs from Virology Journal
#1,972
of 3,071 outputs
Outputs of similar age
#192,162
of 301,794 outputs
Outputs of similar age from Virology Journal
#22
of 44 outputs
Altmetric has tracked 23,100,534 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,071 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.8. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 301,794 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.