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Expression of pluripotency markers in the bovine uterus with adenomyosis

Overview of attention for article published in Reproductive Biology and Endocrinology, September 2015
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Title
Expression of pluripotency markers in the bovine uterus with adenomyosis
Published in
Reproductive Biology and Endocrinology, September 2015
DOI 10.1186/s12958-015-0106-0
Pubmed ID
Authors

Martyna Łupicka, Barbara Socha, Agata Szczepańska, Anna Korzekwa

Abstract

Adenomyosis is a proliferative uterine dysfunction with unknown aetiology. One possible mechanism of its development involves disturbances in stem cell differentiation in uterine tissue. Previously, we identified pluripotent/multipotent cells in the bovine uterus, therefore our present study focused on determining expression of pluripotency markers, NANOG, OCT4 and SOX2, in bovine adenomyotic tissues and cells. Immunolocalisation revealed protein expression of NANOG, OCT4 and SOX2 in both normal and adenomyotic uteri. mRNA expression for NANOG and OCT4 was increased in tissues obtained from uteri with adenomyosis compared to controls, but at the protein level there were no significant differences. mRNA expression for all three pluripotency markers was higher in myometrial cells isolated from uteri with adenomyotic lesions than in those isolated from normal uteri. The protein level of NANOG and SOX2 was decreased in stromal cells from adenomyotic tissues, whereas the level of OCT4 and SOX2 was increased in myometrial cells obtained from dysfunctional uteri. The results indicate significant changes in expression of pluripotency markers in adenomyotic compared to normal uteri, which suggest the involvement of uterine stem cells in adenomyosis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 12%
Student > Bachelor 2 12%
Researcher 2 12%
Student > Ph. D. Student 1 6%
Librarian 1 6%
Other 2 12%
Unknown 7 41%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 24%
Veterinary Science and Veterinary Medicine 2 12%
Environmental Science 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Computer Science 1 6%
Other 0 0%
Unknown 8 47%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2015.
All research outputs
#18,429,163
of 22,830,751 outputs
Outputs from Reproductive Biology and Endocrinology
#665
of 974 outputs
Outputs of similar age
#197,331
of 274,379 outputs
Outputs of similar age from Reproductive Biology and Endocrinology
#9
of 16 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 974 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 10.0. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,379 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.