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Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies

Overview of attention for article published in BMC Systems Biology, January 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

twitter
1 tweeter
wikipedia
1 Wikipedia page

Citations

dimensions_citation
53 Dimensions

Readers on

mendeley
61 Mendeley
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Title
Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies
Published in
BMC Systems Biology, January 2011
DOI 10.1186/1752-0509-5-193
Pubmed ID
Authors

Stacey D Finley, Marianne O Engel-Stefanini, PI Imoukhuede, Aleksander S Popel

Abstract

Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis, and its role in cancer biology has been widely studied. Many cancer therapies target angiogenesis, with a focus being on VEGF-mediated signaling such as antibodies to VEGF. However, it is difficult to predict the effects of VEGF-neutralizing agents. We have developed a whole-body model of VEGF kinetics and transport under pathological conditions (in the presence of breast tumor). The model includes two major VEGF isoforms VEGF121 and VEGF165, receptors VEGFR1, VEGFR2 and co-receptors Neuropilin-1 and Neuropilin-2. We have added receptors on parenchymal cells (muscle fibers and tumor cells), and incorporated experimental data for the cell surface density of receptors on the endothelial cells, myocytes, and tumor cells. The model is applied to investigate the action of VEGF-neutralizing agents (called "anti-VEGF") in the treatment of cancer.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 60 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 18%
Student > Bachelor 10 16%
Student > Master 10 16%
Researcher 9 15%
Student > Doctoral Student 5 8%
Other 9 15%
Unknown 7 11%
Readers by discipline Count As %
Engineering 17 28%
Agricultural and Biological Sciences 13 21%
Medicine and Dentistry 9 15%
Biochemistry, Genetics and Molecular Biology 8 13%
Chemistry 2 3%
Other 6 10%
Unknown 6 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2020.
All research outputs
#5,136,150
of 16,641,846 outputs
Outputs from BMC Systems Biology
#273
of 1,107 outputs
Outputs of similar age
#61,765
of 218,078 outputs
Outputs of similar age from BMC Systems Biology
#17
of 63 outputs
Altmetric has tracked 16,641,846 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,107 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 218,078 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.