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Oral administration of inactivated porcine epidemic diarrhea virus activate DCs in porcine Peyer’s patches

Overview of attention for article published in BMC Veterinary Research, August 2018
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Title
Oral administration of inactivated porcine epidemic diarrhea virus activate DCs in porcine Peyer’s patches
Published in
BMC Veterinary Research, August 2018
DOI 10.1186/s12917-018-1568-z
Pubmed ID
Authors

Chen Yuan, En Zhang, Lulu Huang, Jialu Wang, Qian Yang

Abstract

Peyer's patches (PPs) can be considered as the immune site of the intestine. Within PPs, Dendritic cells (DCs) can uptake antigens from the gut lumen by extending dendrites into epithelium, and process it and then present to lymphocytes, which effectively antigen produces an immune response. Porcine epidemic diarrhea virus (PEDV) is the causative agent of porcine epidemic diarrhea (PED), an acute and highly contagious enteric viral disease. The interaction between inactivated porcine epidemic diarrhea virus and porcine monocyte-derived dendritic cells (Mo-DCs) has been reported. However, little is known about the interaction between inactivated PEDV and DCs in porcine PPs. In this study, for the first time we investigated the role of DCs in porcine PPs after oral administration inactivated PEDV. Firstly, a method to isolate DCs from porcine PPs was established, in which the purity of SWC3a+/MHC-II+ DCs was more than 90%. Our findings clearly indicate that DCs in porcine PPs after oral administration of inactivated PEDV not only stimulated the proliferation of allogeneic lymphocytes, but also secreted cytokines (IL-1, IL-4). Furthermore, the number of DCs and IgA+ cells in porcine intestinal mucosal significantly increased and the levels of anti-PEDV specific IgG antibody in the serum and SIgA antibody in the feces increased after oral administration inactivated PEDV. Our findings indicate that oral administration of inactivated PEDV activate DCs in porcine Peyer's patches and inactivated PEDV may be a useful and safe vaccine to trigger adaptive immunity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 28%
Researcher 5 17%
Student > Bachelor 4 14%
Librarian 2 7%
Student > Ph. D. Student 2 7%
Other 3 10%
Unknown 5 17%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 8 28%
Biochemistry, Genetics and Molecular Biology 5 17%
Agricultural and Biological Sciences 3 10%
Nursing and Health Professions 1 3%
Business, Management and Accounting 1 3%
Other 3 10%
Unknown 8 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2018.
All research outputs
#11,870,795
of 13,385,815 outputs
Outputs from BMC Veterinary Research
#1,580
of 1,962 outputs
Outputs of similar age
#232,389
of 269,384 outputs
Outputs of similar age from BMC Veterinary Research
#17
of 22 outputs
Altmetric has tracked 13,385,815 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,962 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.