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Monitoring inflammation and airway remodeling by fluorescence molecular tomography in a chronic asthma model

Overview of attention for article published in Journal of Translational Medicine, October 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (71st percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

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2 tweeters
patent
1 patent

Citations

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15 Dimensions

Readers on

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32 Mendeley
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Title
Monitoring inflammation and airway remodeling by fluorescence molecular tomography in a chronic asthma model
Published in
Journal of Translational Medicine, October 2015
DOI 10.1186/s12967-015-0696-5
Pubmed ID
Authors

Fabio Stellari, Angelo Sala, Francesca Ruscitti, Chiara Carnini, Prisco Mirandola, Marco Vitale, Maurizio Civelli, Gino Villetti

Abstract

Asthma is a multifactorial disease for which a variety of mouse models have been developed. A major drawback of these models is represented by the transient nature of the airway pathology peaking 24-72 h after challenge and resolving in 1-2 weeks. We characterized the temporal evolution of pulmonary inflammation and tissue remodeling in a recently described mouse model of chronic asthma (8 week treatment with 3 allergens: Dust mite, Ragweed, and Aspergillus; DRA). We studied the DRA model taking advantage of fluorescence molecular tomography (FMT) imaging using near-infrared probes to non-invasively evaluate lung inflammation and airway remodeling. At 4, 6, 8 or 11 weeks, cathepsin- and metalloproteinase-dependent fluorescence was evaluated in vivo. A subgroup of animals, after 4 weeks of DRA, was treated with Budesonide (100 µg/kg intranasally) daily for 4 weeks. Cathepsin-dependent fluorescence in DRA-sensitized mice resulted significantly increased at 6 and 8 weeks, and was markedly inhibited by budesonide. This fluorescent signal well correlated with ex vivo analysis such as bronchoalveolar lavage eosinophils and pulmonary inflammatory cell infiltration. Metalloproteinase-dependent fluorescence was significantly increased at 8 and 11 weeks, nicely correlated with collagen deposition, as evaluated histologically by Masson's Trichrome staining, and airway epithelium hypertrophy, and was only partly inhibited by budesonide. FMT proved suitable for longitudinal studies to evaluate asthma progression, showing that cathepsin activity could be used to monitor inflammatory cell infiltration while metalloproteinase activity parallels airway remodeling, allowing the determination of steroid treatment efficacy in a chronic asthma model in mice.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 41%
Student > Ph. D. Student 6 19%
Other 3 9%
Professor > Associate Professor 2 6%
Student > Master 2 6%
Other 1 3%
Unknown 5 16%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 9 28%
Medicine and Dentistry 5 16%
Biochemistry, Genetics and Molecular Biology 3 9%
Veterinary Science and Veterinary Medicine 2 6%
Agricultural and Biological Sciences 2 6%
Other 5 16%
Unknown 6 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2019.
All research outputs
#5,533,401
of 20,221,309 outputs
Outputs from Journal of Translational Medicine
#818
of 3,535 outputs
Outputs of similar age
#82,979
of 299,490 outputs
Outputs of similar age from Journal of Translational Medicine
#62
of 350 outputs
Altmetric has tracked 20,221,309 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,535 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.8. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,490 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 350 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.