↓ Skip to main content

A genetic framework for H2O2 induced cell death in Arabidopsis thaliana

Overview of attention for article published in BMC Genomics, October 2015
Altmetric Badge

Mentioned by

twitter
2 X users

Citations

dimensions_citation
41 Dimensions

Readers on

mendeley
100 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
A genetic framework for H2O2 induced cell death in Arabidopsis thaliana
Published in
BMC Genomics, October 2015
DOI 10.1186/s12864-015-1964-8
Pubmed ID
Authors

Eve Kaurilind, Enjun Xu, Mikael Brosché

Abstract

To survive in a changing environment plants constantly monitor their surroundings. In response to several stresses and during photorespiration plants use reactive oxygen species as signaling molecules. The Arabidopsis thaliana catalase2 (cat2) mutant lacks a peroxisomal catalase and under photorespiratory conditions accumulates H2O2, which leads to activation of cell death. A cat2 double mutant collection was generated through crossing and scored for cell death in different assays. Selected double mutants were further analyzed for photosynthetic performance and H2O2 accumulation. We used a targeted mutant analysis with more than 50 cat2 double mutants to investigate the role of stress hormones and other defense regulators in H2O2-mediated cell death. Several transcription factors (AS1, MYB30, MYC2, WRKY70), cell death regulators (RCD1, DND1) and hormone regulators (AXR1, ERA1, SID2, EDS1, SGT1b) were essential for execution of cell death in cat2. Genetic loci required for cell death in cat2 was compared with regulators of cell death in spontaneous lesion mimic mutants and led to the identification of a core set of plant cell death regulators. Analysis of gene expression data from cat2 and plants undergoing cell death revealed similar gene expression profiles, further supporting the existence of a common program for regulation of plant cell death. Our results provide a genetic framework for further study on the role of H2O2 in regulation of cell death. The hormones salicylic acid, jasmonic acid and auxin, as well as their interaction, are crucial determinants of cell death regulation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 1%
Spain 1 1%
Slovenia 1 1%
Unknown 97 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 22%
Student > Ph. D. Student 21 21%
Student > Master 15 15%
Student > Doctoral Student 8 8%
Student > Bachelor 6 6%
Other 16 16%
Unknown 12 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 53 53%
Biochemistry, Genetics and Molecular Biology 25 25%
Environmental Science 3 3%
Philosophy 1 1%
Business, Management and Accounting 1 1%
Other 1 1%
Unknown 16 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2015.
All research outputs
#18,429,163
of 22,830,751 outputs
Outputs from BMC Genomics
#8,183
of 10,655 outputs
Outputs of similar age
#204,158
of 283,600 outputs
Outputs of similar age from BMC Genomics
#310
of 354 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,655 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,600 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 354 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.