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A genetic framework for H2O2 induced cell death in Arabidopsis thaliana

Overview of attention for article published in BMC Genomics, October 2015
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Title
A genetic framework for H2O2 induced cell death in Arabidopsis thaliana
Published in
BMC Genomics, October 2015
DOI 10.1186/s12864-015-1964-8
Pubmed ID
Authors

Eve Kaurilind, Enjun Xu, Mikael Brosché

Abstract

To survive in a changing environment plants constantly monitor their surroundings. In response to several stresses and during photorespiration plants use reactive oxygen species as signaling molecules. The Arabidopsis thaliana catalase2 (cat2) mutant lacks a peroxisomal catalase and under photorespiratory conditions accumulates H2O2, which leads to activation of cell death. A cat2 double mutant collection was generated through crossing and scored for cell death in different assays. Selected double mutants were further analyzed for photosynthetic performance and H2O2 accumulation. We used a targeted mutant analysis with more than 50 cat2 double mutants to investigate the role of stress hormones and other defense regulators in H2O2-mediated cell death. Several transcription factors (AS1, MYB30, MYC2, WRKY70), cell death regulators (RCD1, DND1) and hormone regulators (AXR1, ERA1, SID2, EDS1, SGT1b) were essential for execution of cell death in cat2. Genetic loci required for cell death in cat2 was compared with regulators of cell death in spontaneous lesion mimic mutants and led to the identification of a core set of plant cell death regulators. Analysis of gene expression data from cat2 and plants undergoing cell death revealed similar gene expression profiles, further supporting the existence of a common program for regulation of plant cell death. Our results provide a genetic framework for further study on the role of H2O2 in regulation of cell death. The hormones salicylic acid, jasmonic acid and auxin, as well as their interaction, are crucial determinants of cell death regulation.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 1%
Spain 1 1%
Slovenia 1 1%
Unknown 89 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 24%
Student > Ph. D. Student 20 22%
Student > Master 15 16%
Student > Doctoral Student 7 8%
Student > Bachelor 5 5%
Other 15 16%
Unknown 8 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 54%
Biochemistry, Genetics and Molecular Biology 24 26%
Environmental Science 3 3%
Philosophy 1 1%
Business, Management and Accounting 1 1%
Other 1 1%
Unknown 12 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2015.
All research outputs
#9,036,319
of 11,293,566 outputs
Outputs from BMC Genomics
#5,303
of 6,784 outputs
Outputs of similar age
#171,692
of 250,832 outputs
Outputs of similar age from BMC Genomics
#344
of 411 outputs
Altmetric has tracked 11,293,566 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,784 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,832 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 411 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.