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Clinical, molecular and drug sensitivity pattern of mycobacterial isolates from extra-pulmonary tuberculosis cases in Addis Ababa, Ethiopia

Overview of attention for article published in BMC Infectious Diseases, October 2015
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Title
Clinical, molecular and drug sensitivity pattern of mycobacterial isolates from extra-pulmonary tuberculosis cases in Addis Ababa, Ethiopia
Published in
BMC Infectious Diseases, October 2015
DOI 10.1186/s12879-015-1177-4
Pubmed ID
Authors

Workneh Korma, Adane Mihret, Jemal Hussien, Richard Anthony, Mekuria Lakew, Abraham Aseffa

Abstract

In conjunction with the spread of HIV infection, tuberculosis (TB) remains a major cause of illness and death worldwide. The Ethiopian national report reveals that extra pulmonary tuberculosis is on the rise and that case detection rate is exceeding that of smear positive or negative cases in many parts of the country. Different studies indicated that host and/or pathogen related factors are associated with the rise of extra pulmonary cases. However, the reason for this is not clearly known in our setting. Specimens were taken from clinically suspected extra pulmonary patients and confirmed by cytology, histopathology and culture. Deletion typing and Spoligotyping was utilized to identify the strains. The isolates were then assigned to lineage using conformal Bayesian network (rules model) algorithm and dendrograms were drawn using UPGMA methods. In addition, drug sensitivity test was done using the indirect proportion and 24 well plate methods. Out of the 200 clinically suspected extra pulmonary tuberculosis patients, 106 (53 %) were between 15 and 35 years of age and 167 (83.5 %) were new while 33 (16.5 %) were retreatment cases. The culture yield was 29.5 % (59). Of these only one was M. bovis and 58 were M. tuberculosis strains with 31 different spoligotype patterns grouped into seven clusters. The largest cluster (ST53) comprised 12 (20.3 %) isolates. There was higher clustering of CAS isolates in TBLN than in any other form of extra pulmonary tuberculosis cases. Resistance to rifampicin was higher (22 %) than that for INH, STM and EMB (8.1 %, 5 % and 3 % respectively). Out of the 37 isolates tested for resistance, only 2 isolates were resistant for both STM and INH and no MDR strain was found. There is an ongoing active recent transmission among extra pulmonary tuberculosis in the study areas as shown by the presence of clusters. Although no MDR case was observed, there is a risk of emergence of MDR as noted from the high proportion of resistance to rifampicin. Detailed study at population level is recommended to monitor its trend.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 95 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 19%
Researcher 18 19%
Student > Ph. D. Student 10 11%
Student > Doctoral Student 8 8%
Student > Postgraduate 8 8%
Other 19 20%
Unknown 14 15%
Readers by discipline Count As %
Medicine and Dentistry 25 26%
Nursing and Health Professions 15 16%
Immunology and Microbiology 11 12%
Biochemistry, Genetics and Molecular Biology 11 12%
Social Sciences 5 5%
Other 9 9%
Unknown 19 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2016.
All research outputs
#5,510,672
of 7,644,999 outputs
Outputs from BMC Infectious Diseases
#2,249
of 3,441 outputs
Outputs of similar age
#151,056
of 241,743 outputs
Outputs of similar age from BMC Infectious Diseases
#112
of 163 outputs
Altmetric has tracked 7,644,999 research outputs across all sources so far. This one is in the 24th percentile – i.e., 24% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,441 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
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