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Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells

Overview of attention for article published in BMC Cancer, February 2018
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Title
Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells
Published in
BMC Cancer, February 2018
DOI 10.1186/s12885-018-4086-2
Pubmed ID
Authors

Carlos M. Galmarini, Maud Martin, Benjamin Pierre Bouchet, María José Guillen-Navarro, Marta Martínez-Diez, Juan Fernando Martinez-Leal, Anna Akhmanova, Pablo Aviles

Abstract

Vascular supply of tumors is one of the main targets for cancer therapy. Here, we investigated if plocabulin (PM060184), a novel marine-derived microtubule-binding agent, presents antiangiogenic and vascular-disrupting activities. The effects of plocabulin on microtubule network and dynamics were studied on HUVEC endothelial cells. We have also studied its effects on capillary tube structures formation or destabilization in three-dimensional collagen matrices. In vivo experiments were performed on different tumor cell lines. In vitro studies show that, at picomolar concentrations, plocabulin inhibits microtubule dynamics in endothelial cells. This subsequently disturbs the microtubule network inducing changes in endothelial cell morphology and causing the collapse of angiogenic vessels, or the suppression of the angiogenic process by inhibiting the migration and invasion abilities of endothelial cells. This rapid collapse of the endothelial tubular network in vitro occurs in a concentration-dependent manner and is observed at concentrations lower than that affecting cell survival. The in vitro findings were confirmed in tumor xenografts where plocabulin treatment induced a large reduction in vascular volume and induction of extensive necrosis in tumors, consistent with antivascular effects. Altogether, these data suggest that an antivascular mechanism is contributing to the antitumor activities of plocabulin.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 17%
Student > Master 5 17%
Student > Ph. D. Student 4 13%
Researcher 2 7%
Other 1 3%
Other 1 3%
Unknown 12 40%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 17%
Chemistry 4 13%
Medicine and Dentistry 4 13%
Agricultural and Biological Sciences 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 3 10%
Unknown 11 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2018.
All research outputs
#10,664,940
of 13,406,897 outputs
Outputs from BMC Cancer
#3,325
of 5,040 outputs
Outputs of similar age
#200,354
of 268,042 outputs
Outputs of similar age from BMC Cancer
#1
of 1 outputs
Altmetric has tracked 13,406,897 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,040 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them