Title |
The age of enlightenment in melanoma immunotherapy
|
---|---|
Published in |
Journal for Immunotherapy of Cancer, August 2018
|
DOI | 10.1186/s40425-018-0397-8 |
Pubmed ID | |
Authors |
Mark R. Albertini |
Abstract |
An updated survival analysis by Callahan et al. published in the February 1, 2018 issue of the Journal of Clinical Oncology reported a 3-year overall survival (OS) rate of 63% for 94 patients with previously treated or untreated advanced melanoma who received ipilimumab and nivolumab as concurrent therapy in a phase 1 dose escalation study CA209-004 (n = 53) or in an expansion cohort with the dose and schedule of concurrent ipilimumab and nivolumab now approved for patients with unresectable or metastatic melanoma (n = 41). While this 3-year OS rate of 63% in patients with measurable, unresectable stage III or IV melanoma is an impressive accomplishment that compares very favorably with historical metastatic melanoma survival rates, findings from larger phase 3 studies are needed to determine whether combination immunotherapy significantly improves survival more than single agent immunotherapy with PD-1 blockade. This Commentary discusses the transition from the dark ages to the age of enlightenment in melanoma immunotherapy and provides a roadmap for a better tomorrow for patients with metastatic melanoma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 10 | 77% |
Italy | 2 | 15% |
Unknown | 1 | 8% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 38% |
Practitioners (doctors, other healthcare professionals) | 4 | 31% |
Scientists | 3 | 23% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 16% |
Student > Master | 8 | 13% |
Other | 7 | 11% |
Student > Ph. D. Student | 7 | 11% |
Student > Bachelor | 5 | 8% |
Other | 8 | 13% |
Unknown | 17 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 27% |
Biochemistry, Genetics and Molecular Biology | 8 | 13% |
Agricultural and Biological Sciences | 5 | 8% |
Immunology and Microbiology | 4 | 6% |
Chemistry | 3 | 5% |
Other | 7 | 11% |
Unknown | 18 | 29% |