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Composite neuroendocrine carcinoma and squamous cell carcinoma with regional lymph node metastasis: a case report

Overview of attention for article published in Journal of Medical Case Reports, August 2018
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Title
Composite neuroendocrine carcinoma and squamous cell carcinoma with regional lymph node metastasis: a case report
Published in
Journal of Medical Case Reports, August 2018
DOI 10.1186/s13256-018-1775-z
Pubmed ID
Authors

Shintaro Fujihara, Masahiko Kobayashi, Masako Nishi, Tatsuo Yachida, Akira Yoshitake, Akihiro Deguchi, Atsushi Muraoka, Hideki Kobara, Tsutomu Masaki

Abstract

Neuroendocrine cell carcinoma is a rare variant of esophageal carcinoma. The characteristic clinical features and diagnosis of superficial neuroendocrine cell carcinoma remain to be established. We report a rare case of superficial coexistence of neuroendocrine cell carcinoma with squamous cell carcinoma treated by endoscopic submucosal dissection, and regional lymph node metastasis was detected after additional surgical treatment. A 77-year-old Japanese man with esophageal squamous cell carcinoma received endoscopic submucosal dissection in en-bloc resection. Histopathological findings showed that lymphovascular invasion by the neuroendocrine cell carcinoma component occurred in the deep part of the muscularis mucosa. Regional lymph node metastasis was identified after additional surgical treatment. After surgical treatment, our patient received chemotherapy consisting of etoposide and carboplatin for 3 months. He is alive and shows no sign of disease recurrence 12 months after surgery. This case report highlights the fact that even if neuroendocrine cell carcinoma is small and limited to superficial, the tumor has the potential for metastasis if lymphovascular invasion by the neuroendocrine cell carcinoma component occurs. In addition, this case indicates the necessity of close follow-up of small neuroendocrine cell carcinoma after treatment.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 3 30%
Researcher 2 20%
Unspecified 1 10%
Lecturer > Senior Lecturer 1 10%
Unknown 3 30%
Readers by discipline Count As %
Medicine and Dentistry 4 40%
Nursing and Health Professions 1 10%
Unspecified 1 10%
Unknown 4 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2018.
All research outputs
#18,647,094
of 23,100,534 outputs
Outputs from Journal of Medical Case Reports
#2,288
of 3,966 outputs
Outputs of similar age
#256,730
of 334,198 outputs
Outputs of similar age from Journal of Medical Case Reports
#55
of 81 outputs
Altmetric has tracked 23,100,534 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,966 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,198 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.