Title |
Ribonucleotide reduction - horizontal transfer of a required function spans all three domains
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Published in |
BMC Ecology and Evolution, December 2010
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DOI | 10.1186/1471-2148-10-383 |
Pubmed ID | |
Authors |
Daniel Lundin, Simonetta Gribaldo, Eduard Torrents, Britt-Marie Sjöberg, Anthony M Poole |
Abstract |
Ribonucleotide reduction is the only de novo pathway for synthesis of deoxyribonucleotides, the building blocks of DNA. The reaction is catalysed by ribonucleotide reductases (RNRs), an ancient enzyme family comprised of three classes. Each class has distinct operational constraints, and are broadly distributed across organisms from all three domains, though few class I RNRs have been identified in archaeal genomes, and classes II and III likewise appear rare across eukaryotes. In this study, we examine whether this distribution is best explained by presence of all three classes in the Last Universal Common Ancestor (LUCA), or by horizontal gene transfer (HGT) of RNR genes. We also examine to what extent environmental factors may have impacted the distribution of RNR classes. |
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Geographical breakdown
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New Zealand | 1 | 1% |
Ukraine | 1 | 1% |
Unknown | 90 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 19 | 20% |
Researcher | 17 | 18% |
Student > Master | 16 | 17% |
Student > Bachelor | 7 | 8% |
Student > Postgraduate | 6 | 6% |
Other | 14 | 15% |
Unknown | 14 | 15% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 5 | 5% |
Chemistry | 3 | 3% |
Environmental Science | 3 | 3% |
Other | 9 | 10% |
Unknown | 17 | 18% |