Title |
Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling
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Published in |
Respiratory Research, October 2015
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DOI | 10.1186/s12931-015-0296-1 |
Pubmed ID | |
Authors |
Dale D. Tang |
Abstract |
Asthma is characterized by airway hyperresponsiveness and airway remodeling, which are largely attributed to increased airway smooth muscle contractility and cell proliferation. It is known that both chemical and mechanical stimulation regulates smooth muscle contraction. Recent studies suggest that contractile activation and mechanical stretch induce actin cytoskeletal remodeling in smooth muscle. However, the mechanisms that control actin cytoskeletal reorganization are not completely elucidated. This review summarizes our current understanding regarding how actin-associated proteins may regulate remodeling of the actin cytoskeleton in airway smooth muscle. In particular, there is accumulating evidence to suggest that Abelson tyrosine kinase (Abl) plays a critical role in regulating airway smooth muscle contraction and cell proliferation in vitro, and airway hyperresponsiveness and remodeling in vivo. These studies indicate that Abl may be a novel target for the development of new therapy to treat asthma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 75% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Unknown | 67 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 29% |
Researcher | 10 | 15% |
Student > Postgraduate | 8 | 12% |
Student > Doctoral Student | 8 | 12% |
Student > Bachelor | 4 | 6% |
Other | 8 | 12% |
Unknown | 10 | 15% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 14 | 21% |
Agricultural and Biological Sciences | 14 | 21% |
Medicine and Dentistry | 12 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Engineering | 2 | 3% |
Other | 9 | 13% |
Unknown | 13 | 19% |